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Discussion Session on LET and Chromosome Damage

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Part of the book series: NATO ASI Series ((ASIH,volume 54))

Abstract

Chromosome damage may be said to represent the final manifestation of the early effects of ionizing radiation in that chromosomal events can probably be linked more closely to cell death than any of the other measures of radiation effect so far discussed. Furthermore, until the advent of clonogenic survival assay in the 1950’s, the study of chromosome damage formed the basis for most of our knowledge of the cellular effects of irradiation and even today conventional chromosome studies still provide much information with regard to the underlying mechanisms of radiation action.

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References

  • Cornforth MN and Bedford JS (1985) On the nature of the defect in cells from individuals with ataxia-telangiectasia. Science 227:1589–1591

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  • Johnson RT and Rao RN (1970) Mammalian cell fusion: Induction of premature chromosome condensation in interphase nuclei. Nature (London) 226:717–722

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  • Revell SH (1983) Relationship between chromosome damage and cell death. Radiation-induced Chromosome Damage in Man. Liss AR, New York (ed), pp 215–233

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© 1991 Springer-Verlag Berlin Heidelberg

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Peacock, J.H. (1991). Discussion Session on LET and Chromosome Damage. In: Fielden, E.M., O’Neill, P. (eds) The Early Effects of Radiation on DNA. NATO ASI Series, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75148-6_42

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  • DOI: https://doi.org/10.1007/978-3-642-75148-6_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75150-9

  • Online ISBN: 978-3-642-75148-6

  • eBook Packages: Springer Book Archive

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