The Effect of Environment upon DNA Free Radicals
Since 1985 a continued effort has been made to understand the primary damage caused by direct radiation effects to the constituents of the DNA molecule. The main motivation for initiating these studies was the report from a Swedish group (Gräslund et al. 1971). Using ESR spectroscopy it was proposed that in oriented fibres of DNA mainly two radical species are formed and trapped at low temperatures.
KeywordsAdduct Adenine Pyrimidine Thymidine Purine
Unable to display preview. Download preview PDF.
- Bernhard WA (1981) Solid-state radiation chemistry of DNA: The bases. Adv Radiat Biol 9:199–280Google Scholar
- Boon PJ, Cullis PM, Symons MCR, Wren BW (1984) Effects of ionizing radiation on deoxyribonucleic acid and related systems. Part I. The role of oxygen. J. Chem Soc Perk Trans 11:1393–1399Google Scholar
- Close DM (1984) General discussion. Faraday Discuss Chem Soc 78:227–228Google Scholar
- Close DM, Nelson WH, Sagstuen E (1987b) EPR and ENDOR study of x-irradiated single crystals of purines at 4.2 K. In: Weil JA (ed) Electron magnetic resonance of the solid state. The Canadian Soc Chem, Ottawa, p 237Google Scholar
- Cullis PM, Symons MCR (1986) Electron Spin Resonance Studies of the Mechanisms of Radiation Damage to DNA. In:Simic MG, Grossmann L, Upton AC (eds) Mechanism of DNA damage and repair. Plenum, New York London, p 29Google Scholar
- Flossmann W, Zehner H, Müller A (1980) Radicals produced in single crystals of thymine derivatives by uv and x-rays. Z Naturforsch 35c:20–29Google Scholar
- Hole EO, Sagstuen E, Nelson WH, Close DM (1990) Radiation damage to guanine hydrobromide monohydrate. Solid state ESR and ENDOR between 8 and 295 K. Radiat Res (to be published)Google Scholar
- Hole EO, Sagstuen E, Nelson WH, Close DM (1990b) Primary reduction and oxidation of thymine derivatives: ESR/ENDOR of thymidine and 1-methylthymine x-irradiated at 10 K. J Phys Chem (to be published)Google Scholar
- Pershan PS, Schulman BJ, Wyluda BJ, Eisinger J (1964) Electron spin resonance of irradiated DNA. Physics 1:163–182Google Scholar
- Rhodes CJ, Podmore ID, Symons MCR (1988) Radical cations of N,N-dimethyluracil and N,N-dimethylthymine. J Chem Res (S) 120–121Google Scholar