What Basis for the Development of Radiation-Induced DNA Damage?

  • Hooshang Nikjoo
Part of the NATO ASI Series book series (volume 54)


To account for the observed biological effects a multitude of different physical and chemical processes have been put forward todate. In terms of time domains molecular effects are referred to as ‘direct-effect’ (D) and ‘indirect-effect’ (ID). There exist a number of definitions for these terms: (D) effect due to ionisation or excitation of the DNA molecule, (D) effects not modified by radical scavenging species, (D) thermal excitation of DNA by internal conversion, (ID) damage caused by reactive species and (ID) damage due to finite migration of free radicals.


Indirect Effect Reactive Species Energy Deposition Internal Conversion Thermal Excitation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Hooshang Nikjoo
    • 1
  1. 1.MRC Radiobiology UnitChilton, OxonUK

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