Abstract
Understanding the biochemical mechanisms associated with the production of DNA strand breaks by ionizing radiation is a subject of great interest. Numerous attempts have been made to elucidate many aspects of these phenomena (Roots et al., 1985; Pohlit and Drenkard, 1985; Ward, 1988) and indeed most of our present knowledge is due to the efforts of experimental radiation biochemists. For a better quantitative understanding these efforts need to be complemented by theoretical modeling in order to correlate energy loss events with the corresponding biochemical changes and eventually to the yields of strand breaks.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Arnott S and Hukins DWL (1972) Optimized parameters for A-DNA and B-DNA. Biochem Biophys Res Comm 47:1504–1509
Charlton DE and Humm JL (1988) A method of calculating initial DNA strand breakage following the decay of incorporated 125I. Int J Radiat Biol 53:353–365
Chatterjee A, Koehl P, and Magee JL (1986) Theoretical consideration of the chemical pathways for radiation-induced strand breaks. Adv Space Res 6:97–105
Chatterjee A (1989) Radiobiological effects of high-LET particles: DNA strand breaks. Nucl Inst & Methods in Physics Res A280:439–448
Chatter A and Holley WR (1990) Direct and Indirect Effects in DNA Aqueous Solution. J Cell Biochem Suppl 14A
Goodhead DT and Nikjoo H (1989) Track structure analysis of ultrasoft X-rays compared to high- and low-LET radiations. Int J Radiat Biol 55:513–529
Holley WR, Chatterjee A, Magee JL (1990) Production of DNA strand breaks by direct effects of heavy charged particles. Rad Res 121:161–168
Magee JL and Chatterjee A (1978) Theory of the chemical effects of high-energy electrons. J Phys Chem 82:2219–2226
Magee JL and Chatterjee A (1980) Radiation chemistry of heavy particle tracks. 1. General considerations. J Phys Chem 84:3529–3536
Pohlit W and Drenkard S (1985) Quantitative determination of the contribution of indirect and direct radiation action to the production of lethal lesions in mammalian cells. Rad Prot Dosimetry 13:195–198
Roots R, Chatterjee A, Chang P, Lommel L, and Blakely EA (1985) Characterization of hydroxyl radical induced damage after sparsely and densely ionizing radiation. Int J Radiat Biol 47:157–166
Ward JF (1988) DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Repairability. Prog Nuclei Acid Res & Mol Biol 35:95–125
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Holley, W.R., Chatterjee, A. (1991). The Application of Chemical Models to Cellular DNA Damage. In: Fielden, E.M., O’Neill, P. (eds) The Early Effects of Radiation on DNA. NATO ASI Series, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75148-6_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-75148-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75150-9
Online ISBN: 978-3-642-75148-6
eBook Packages: Springer Book Archive