The Role of Radiation Induced Charge Migration with DNA: ESR Studies

  • Martyn C. R. Symons
Part of the NATO ASI Series book series (volume 54)


E.s.r. spectroscopy is useful for studying primary processes in irradiated DNA. From the results it is argued that primary radical-cations migrate into the DNA base system, becoming trapped at guanine by proton loss (G+–H+). Similarly, ejected electrons migrate to, and within, the base system, becoming trapped at cytidine (C·H+) or thymine (T·H+) by proton attachment. When dilute frozen aqueous systems are used, (T·H+) seems to be a major product and is well separated from the (G·+–H+) units. It is stressed that trapping is probably controlled by the rates of protonation and that these vary greatly with temperature and environment. Sites of such protonation are considered, and these are also likely to be very sensitive to the conditions used.


Electron Spin Resonance Deoxyribonucleic Acid Electron Spin Resonance Study Electronic Magnetic Resonance Charge Migration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Martyn C. R. Symons
    • 1
  1. 1.Department of ChemistryThe UniversityLeicesterUK

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