The Structure of the Antibiotic Binding Sites in Bacterial Ribosomes
With only a few exceptions, antibiotics inhibit protein synthesis by binding to the ribosome and blocking some of the several functions that the particle performs in this metabolic process (Vazquez, 1979; Gale et al. 1981). The antibiotic binding sites must be located in regions of the ribosomal particle closely related to the inhibited activity and, obviously, the definition of the structure of these interaction sites will provide important information for the understanding of both the drug mode of action and the function of the ribosome.
KeywordsDomain Versus Lactone Ring Photoaffinity Label Drug Binding Site Ribosome Structure
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