Skip to main content

Part of the book series: NATO ASI Series ((ASIH,volume 56))

  • 116 Accesses

Abstract

This review will describe experiments aimed at answering two questions raised by the recent convergence of research on signal-transducing G proteins and oncogenes: What roles do individual G proteins play in normal regulation of cell proliferation? How do dominantly acting G protein oncogenes contribute to tumorigenesis, in experimental systems and in human cancer?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abood ME, Hurley JB, Pappone M-C, Bourne HR, Stryer L (1982) Functional homology between signal-coupling proteins: Cholera toxin inactivates the GTPase activity of transducin. J Biol Chem 257: 10540–10543

    PubMed  CAS  Google Scholar 

  • Ashkenazi A, Ramachandran J, Capon DJ (1989) Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes. Nature 340: 146–150

    Article  PubMed  CAS  Google Scholar 

  • Billestrup N, Swanson LW, Vale W (1986) Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 83: 6854–6857

    Article  PubMed  CAS  Google Scholar 

  • Bourne HR (1987) G proteins and cAMP. Discovery of a new oncogene in pituitary tumours? Nature 330: 517–518

    Article  PubMed  CAS  Google Scholar 

  • Bourne HR, Sanders DA, McCormick F (1990) The GTPase superfamily. A conserved switch for diverse cell functions. Nature 348: 125–132

    Article  PubMed  CAS  Google Scholar 

  • Cassel D, Pfeuffer T (1978) Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system. Proc Natl Acad Sci USA 75: 2669–2673

    Article  PubMed  CAS  Google Scholar 

  • Fong HKW, Yoshimoto KK, Eversole-Cire P, Simon MI (1988) Identification of a GTP-binding protein a subunit that lacks an apparent ADP- ribosylation site for pertussis toxin. Proc Natl Acad Sci USA 85: 3066–3070

    Article  PubMed  CAS  Google Scholar 

  • Freissmuth M, Casey PJ, Gilman AG (1989) G proteins control diverse pathways of transmembrane signaling. FASEB J 3: 2125–2131

    PubMed  CAS  Google Scholar 

  • Julius D, Livelli TJ, Jessell TM, Axel R (1989) Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244: 1057–1062

    Article  PubMed  CAS  Google Scholar 

  • Kavanaugh WM, Williams LT, Ives HE, Coughlin SR (1988) Serotonin- induced deoxyribnucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitve pathway. Mol Endocrin 2: 599–605

    Article  CAS  Google Scholar 

  • Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR (1990) Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant G§ protein. J Clin Endocrinol Metab in press

    Google Scholar 

  • Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989) GTPase inhibiting mutations activate the α chain of G s and stimulate adenylyl cyclase in human pituitary tumours. Nature 340: 692–696

    Article  PubMed  CAS  Google Scholar 

  • Letterio JJ, Coughlin SR, Williams LT (1986) Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin. Science 234: 1117–1119

    Article  PubMed  CAS  Google Scholar 

  • Lyons J, Landis CA, Harsh G, Vallar L, Griinewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, McCormick F (1990) Two G protein oncogenes in human endocrine tumors. Science 249: 655–659

    Article  PubMed  CAS  Google Scholar 

  • Matsuoka M, Itoh H, Kozasa T, Kaziro Y (1988) Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein a subunit. Proc Natl Acad Sci USA 85: 5384–5388

    Article  PubMed  CAS  Google Scholar 

  • Nemecek GM, Coughlin SR, Handley DA, Moskowitz MA (1986) Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc Natl Acad Sci USA 83: 674–678

    Article  PubMed  CAS  Google Scholar 

  • Paris S, Pouysségur J (1986) Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. EMBO J 5: 55–60

    PubMed  CAS  Google Scholar 

  • Rozengurt E, Erusalimsky J, Mehmet H, Morris C, Ninberg E, Sinnett-Smith J (1988) Signal transduction in mitogenesis: Further evidence for multiple pathways, Cold Spring Harbor Symp. Quant. Biol. 53: 945–954

    Article  PubMed  CAS  Google Scholar 

  • Seuwen K, Magnaldo I, Pouysségur J (1988) Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi protein. Nature 335: 254–256

    Article  PubMed  CAS  Google Scholar 

  • Strathmann M, Wilkie TM, Simon MI (1989) Diversity of the G-protein family: Sequences from five additional a subunits in the mouse. Proc Natl Acad Sci USA 86: 7407–7409

    Article  PubMed  CAS  Google Scholar 

  • Vallar L, Spada A, Giannattasio G (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330: 566–568

    Article  PubMed  CAS  Google Scholar 

  • van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH (1989) Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins. Cell 59: 45–54

    Article  PubMed  Google Scholar 

  • Van Dop C, Tsubokawa M, Bourne HR, Ramachandran J (1984) Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem 259: 696–698

    PubMed  Google Scholar 

  • Zachary I, Masters SB, Bourne HR (1990) Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα. Biochem Biophys Res Comm 168: 1184–1193

    Article  PubMed  CAS  Google Scholar 

  • Zachary I, Millar J, Nanberg E, Higgins T, Rozengurt E (1987) Inhibition of bombesin-induced mitogenesis by pertussis toxin-dissociation from phospholipase C pathway. Biochem Biophys Res Comm 146: 456–463

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bourne, H.R. (1991). G Protein Oncogenes. In: Heilmeyer, L.M.G. (eds) Cellular Regulation by Protein Phosphorylation. NATO ASI Series, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75142-4_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75142-4_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75144-8

  • Online ISBN: 978-3-642-75142-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics