Ribosomal Frameshift and Frame-Jump Sites as Control Points during Elongation

  • Robert B. Weiss
Conference paper
Part of the NATO ASI Series book series (volume 49)

Abstract

As the details of the interactions amongst tRNA, elongation factors, ribosomes and mRNA during the elongation phase of protein synthesis come into increasing focus, several new avenues for translational control have emerged. The recent advent of the high-level ribosomal frameshift site has opened up one such avenue for alternative events during the elongation and termination phases. These extreme cases of sequence-dependent variation in reading frame step size have also exposed a new lead into unsuspected interactions that occur during decoding and translocation. Analysis of ribosomal frameshifting is thus informative both from the standpoint of novel genetic control mechanisms, as well as illuminating new, and complex, macromolecular interactions occurring in protein synthesis.

Keywords

Codon Bacillus Sarcoma Polypeptide Pseudomonas 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Robert B. Weiss
    • 1
  1. 1.The Howard Hughes Medical Institute Department of Human GeneticsThe University of UtahSalt Lake CityUSA

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