The HIV-1 REV Trans-Activator is a Sequence Specific RNA Binding Protein
The pathogenic human retrovirus, human immunodeficiency virus type 1 (HIV-1), is the major etiologic agent of the acquired immunodeficiency syndrome (AIDS) (Fauci, 1988). HIV-1, along with the related primate immunodeficiency viruses, HIV-2 and simian immunodeficiency virus (SIV), is a member of a subfamily of retroviruses known as lentiviruses. Other members of this subfamily include visna virus, caprine arthritis encephalitis virus (CAEV), equine infectious anemia virus (EIAV) and feline immunodeficiency virus (FIV). Lentivirus infection of the susceptible host typically results in a prolonged and chronic disease state affecting the immune and nervous systems as well as cells in a variety of other tissues (reviewed by Haase, 1986). Interestingly, these viruses display complex patterns of gene expression that are very different from those of the extensively studied Type C family of retroviruses. Specifically, proviral activation from a frequently extended period of latency is followed by a pattern of viral gene expression that is markedly temporal. During this time a number of differentially spliced viral transcripts may be observed.
KeywordsArthritis Leukemia Electrophoresis Anemia Polyacrylamide
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