The Role of Ribosomal RNA in the Control of Gene Expression
It is now accepted that ribosomal RNA (rRNA) has an important functional role during the translation of messenger RNA (mRNA). There is evidence for base paired interactions between mRNA and rRNA during initiation, elongation and termination. At initiation the relative level of translation of different mRNAs is determined, in part, by the complementarity between the Shine-Dalgarno sequence of the mRNA and the Anti-Shine-Dalgarno sequence near the 3′ end of 16S rRNA. Several groups have proposed that other regions of 16S rRNA may be involved in similar base paired interactions with mRNA prior to initiation to selectively enhance translation of particular mRNAs. Here we summarize the current data on translational enhancers and identify the proposed sites in 16S rRNA to which they might base pair. The data are presented in a model of the 30S subunit showing a potential pathway for mRNA as it passes over putative rRNA-mRNA contact points during the mRNA selection process, as well as during translation.
KeywordsCodon Hull Ribo
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- Goringer HU, Murgola EJ, Hijazi K, Dahlberg AE, (1990) submitted.Google Scholar
- McCarthy JEG, Sebald W, Gross G, Lammers R, (1986) Gene (Amst.), 41, 201–206Google Scholar
- Olins PO, Devine CS, Rangwala SH, Kavka KS, (1988) Gene (Amst.), 73, 227–235Google Scholar
- Olson HM, Lasater LS, Cann PA, Glitz DG, (1988) J. Biol. Chem., 263, 15196–15204Google Scholar
- Weiss RB, Dunn DM, Atkins JF, Gesteland RF, (1987) Cold Spring Harbor Symp Quant. Biol., 52, 687–693Google Scholar