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Biological Signal Transduction pp 497–509Cite as

Guanylate Cyclase in Signal Transduction of Dictyostelium Discoideum

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Part of the book series: NATO ASI Series ((ASIH,volume 52))

Abstract

External signals that regulate cell functions are often detected by cell surface receptors and transmitted via intracellular second messengers. Such messenger molecules control a wide variety of cellular processes, such as differentiation, proliferation, intermediary metabolism, secretion, changes in cell shape and cell motility. Two of these second messengers are cyclic 3′,5′-adenosine monophosphate (cAMP) and cyclic 3′,5′-guanosine monophosphate (cGMP). While the signalling system using cAMP has been studied extensively, relatively little is known about signal transduction pathways involving cGMP.

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Literature references

  • Arents JC, Van Driel R (1982) Soluble, cytoplasmic cyclic AMP-binding proteins of Dictyostelium discoideum. FEBS Letters 137:201–204

    Article  CAS  Google Scholar 

  • Böhme E, Jung R, Mechler I (1974) Guanylate cyclase in human platelets. Meth. in Enzymol. 28:199–202

    Article  Google Scholar 

  • Chrisman TD, Garbers DL, Parks MA, Hardman JG (1975) Characterization of particulate and soluble guanylate cyclase from rat lung. J. Biol. Chem. 250:374–381

    PubMed  CAS  Google Scholar 

  • Cook NJ, Kaupp UB (1986) The cGMP-dependent cation channel from vertebrate photoreceptors: purification and function reconstitution. Photobiochem. Photobiophys. 13:331–343

    CAS  Google Scholar 

  • De Jonge HR (1976) Cyclic nucleotide-dependent phosphorylation of intestinal epithelium proteins. Nature (London) 262:590–591

    Article  Google Scholar 

  • De Jonge HR, Rosen OM (1977) Self-phosphorylation of cGMP-dependent protein kinase from bovine lung. J. Biol. Chem. 252:2780–2783

    PubMed  Google Scholar 

  • Duda T, Sharma RK (1990) Regulation of guanylate cyclase activity by atrial natriuretic factor and protein kinase C. Molec. Cell. Biochem. 93:179–184

    Article  PubMed  CAS  Google Scholar 

  • Fiscus RR, Rapoport RM, Waldman SA, Murad F (1985) Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochim. Biophys. Acta 846:179–184

    Article  PubMed  CAS  Google Scholar 

  • Garbers DL (1989) Guanylate cyclase, a cell surface receptor. J. Biol. Chem. 264:9103–9106

    PubMed  CAS  Google Scholar 

  • Garbers DL, Dyer E, Hardman JG (1974) Determination of guanosine 3′,5′-monophosphate in tissues and of guanylyl cyclase in rat intestine. J. Biol. Chem. 244:6371–6376

    Google Scholar 

  • Green AA, Newell PC (1975) Evidence for the existence of two types of cAMP binding sites in aggregating cells of Dictyostelium discoideum. Cell 6:129–136

    Article  PubMed  CAS  Google Scholar 

  • Hall AL, Warren V, Condeelis J (1989) Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum. Developm. Biol. 136:517–525

    Article  CAS  Google Scholar 

  • Ho AK, Chik CL, Klein DC (1987) Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation. J. Biol. Chem. 262:10059–10064

    PubMed  CAS  Google Scholar 

  • Janssens PMW, Van Haastert PJM (1987) Molecular basis of transmembrane signal transduction in Dictyostelium discoideum. Microbiol. Rev. 51:396–418

    PubMed  CAS  Google Scholar 

  • Janssens PMW, De Jong CCC (1988) A magnesium-dependent guanylate cyclase in cell-free preparations of Dictyostelium discoideum. Biochem. Biophys. Res. Commun. 150:405–411

    CAS  Google Scholar 

  • Janssens PMW, De Jong CCC, Vink AA, Van Haastert PJM (1989) Regulatory properties of magnesium-dependent guanylate cyclase in Dictyostelium discoideum membranes. J. Biol. Chem. 264:4329–4335

    PubMed  CAS  Google Scholar 

  • Klein DC, Sugden D, Weller JL (1983) Postsynaptic α-adrenergic receptors potentiate the β-adrenergic stimulation of pineal serotonin N-acetyltransferase. Proc. Natl. Acad. Sci. USA 80:599–603

    Article  PubMed  CAS  Google Scholar 

  • Koch KW, Stryer L (1988) Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions. Nature (London) 334:65–66

    Article  Google Scholar 

  • Kuno T, Andresen JW, Kamisaki Y, Waldman SA, Chang LY, Saheki S, Leitman DC, Nakane M, Murad F (1986) Copurification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J. Biol. Chem. 261:5817–5823

    PubMed  CAS  Google Scholar 

  • Lincoln TM, Corbin JD (1983) Characterization and biological role of the cGMP dependent protein kinase. Adv. Cyclic Nucl. Res. 15:139–192

    CAS  Google Scholar 

  • Liu G, Newell PC (1988) Evidence that cyclic GMP regulates myosin intraction with the cytoskeleton during Chemotaxis of Dictyostelium. J. Cell Sci. 90:123–129

    PubMed  CAS  Google Scholar 

  • Loomis WF (1982) The development of Dictyostelium. Acad. Press, New York.

    Google Scholar 

  • Mato JM, Krens FA, Van Haastert PJM, Konijn TM (1977) 3′,5′-cyclic AMP-dependent 3′,5′-cyclic GMP accumulation in Dictyostelium discoideum. Proc. Natl. Acad. Sci. USA 74:2348–2351

    Article  PubMed  CAS  Google Scholar 

  • Mato JM, Woelders H, Konijn TM (1979) Intracellular cyclic GMP-binding proteins in cellular slime molds. J. Bacteriol. 137:169–172

    PubMed  CAS  Google Scholar 

  • Nagao S, Matsuki S, Kanoh H, Ozawa T, Yamada K, Nozawa Y (1990) Site-directed mutagenisis of glutamine residue of calmodulin. J. Biol. Chem. 265:5926–5929

    PubMed  CAS  Google Scholar 

  • Pannbacker RG, Fleischman DE, Reed RW (1972) Cyclic nucleotides phosphodiesterase: high activity in mammalian photoreceptors. Science 175:757–758

    Article  PubMed  CAS  Google Scholar 

  • Preston RR, Saimi Y (1990) Calcium ions and the regulation of motility in Paramecium. Ciliary and Flagellar Membranes: 173–200

    Google Scholar 

  • Schoen CD, Arents JC, Bruin T, Van Driel R (1989) Intracellular localization of secretable cAMP in relaying Dictyostelium discoideum cells. Exp. Cell Res. 181:51–62

    Article  PubMed  CAS  Google Scholar 

  • Schlicher DJ, Casnellie JE, Greengard P (1978) An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum. Nature (London) 273:61–62

    Article  Google Scholar 

  • Sing S, Lowe DG, Thorpe DS, Rodriguez H, Kuang WJ, Dangott LJ, Chinkers M. (1988) Membrane guanylate cyclase is a cell surface receptor with homology to protein kinases. Nature (London) 334:708–710

    Article  Google Scholar 

  • Sugden D, Klein D (1987) A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes. J. Biol. Chem. 262:7447–7450

    PubMed  CAS  Google Scholar 

  • Sun TJ, Van Haastert PJM, Devreotes PM (1990) Surface cAMP receptors mediate multiple responses during development in Dictyostelium discoideum: evidence by antisense mutagenesis. J. Cell Biol. 110:1549–1554

    Article  PubMed  CAS  Google Scholar 

  • Van Haastert PJM, Van Lookeren Campagne MM, Ross FM (1982) Altered cGMP phosphodiesterase activity in chemotactic mutants of Dictyostelium discoideum. FEBS letters 147:149–152

    Article  PubMed  Google Scholar 

  • Walter U (1981) Distribution of cGMP-dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmune assay. Europ. J. Biochem. 118:339–346

    Article  PubMed  CAS  Google Scholar 

  • Wanner R, Wurster B (1990) Cyclic GMP-Activated Protein Kinase from Dictyostelium discoideum. Biochim. Biophys. Acta 1053:179–184

    Article  PubMed  CAS  Google Scholar 

  • Wurster B, Schubiger K, Wick U, Gerisch G (1977) Cyclic GMP in Dictyostelium discoideum. FEBS Lett. 76:141–144

    Article  PubMed  CAS  Google Scholar 

  • Yamazaki A, Uchida S, Stein PJ, Wheeler GL, Bitensky MW (1984) Enzyme regulation and GTP-binding protein: An algorithm of control that includes physical displacement of an inhibitory protein. Adv. Cyclic Nucleotide and Protein Phosphorylation Res.: 16,381–392

    CAS  Google Scholar 

  • Ziegelberger G, Vandenberg MJ, Kaissling KE, Klumpp S, Schultz JE (1990) Cyclic GMP levels and guanylate cyclase activity in pheromone-sensitive antennae of the silkmoths Antheraea polyphemus and Bombyx mori. J. of Neurosci. 10:1217–1225

    CAS  Google Scholar 

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Author information

Author notes

  1. Cor D. Schoen

    Present address: Research Inst. for Plant Protection, Binnenhaven 12, 6709 PD, Wageningen, The Netherlands

Authors and Affiliations

  1. E.C. Slater Institute for Biochemical Research, University of Amsterdam, Plantage Muidergracht 12, 1018 TV, Amsterdam, The Netherlands

    Conchita C. G. M. Schulkes, Cor D. Schoen, Jos C. Arents & Roel van Driel

Authors
  1. Conchita C. G. M. Schulkes
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  2. Cor D. Schoen
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  3. Jos C. Arents
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  4. Roel van Driel
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Editor information

Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Schulkes, C.C.G.M., Schoen, C.D., Arents, J.C., van Driel, R. (1991). Guanylate Cyclase in Signal Transduction of Dictyostelium Discoideum. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_37

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75138-7

  • Online ISBN: 978-3-642-75136-3

  • eBook Packages: Springer Book Archive

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