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Inositol 1,4,5-Triphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Functions, Metabolism and Interconversion

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Biological Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 52))

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Abstract

This paper discusses the metabolism of Ins(1,4,5)P3 and Ins(1,3,4,5)P3, with particular emphasis on the possible contribution of Ins(1,3,4,5)P4 3-phosphatase to a cyclic interconversion of Ins(1,4,5)P3 and Ins(1,3,4,5)P4. The metabolism of the inositol phosphates produced in response to receptor activation, including the characteristics of Ins(1,4,5)P3 3-kinase and of Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase, was recently reviewed in detail by Shears (1989). Current knowledge of the physiological role of these two inositol phosphates will also be outlined: for more extensive reviews, see Berridge (1987) and Berridge and Irvine (1989).

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Authors and Affiliations

  1. School of Biochemistry, The University of Birmingham, P O Box 363, Birmingham, B15 2TT, UK

    M. Teresa Estrada-Garcia, Andrew Craxton, Christopher J. Kirk & Robert H. Michell

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  1. M. Teresa Estrada-Garcia
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  2. Andrew Craxton
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  3. Christopher J. Kirk
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  4. Robert H. Michell
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Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Estrada-Garcia, M.T., Craxton, A., Kirk, C.J., Michell, R.H. (1991). Inositol 1,4,5-Triphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Functions, Metabolism and Interconversion. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_27

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_27

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