Control of Cellular Activity by Protein Phosphorylation-Dephosphorylation: Phosphorylase Kinase from Bovine Stomach Smooth Muscle

  • T. G. Sotiroudis
  • V. G. Zevgolis
  • A. E. Evangelopoulos
Conference paper
Part of the NATO ASI Series book series (volume 52)


Protein phosphorylation process appears to be the most important type of covalent modification involved in cellular functions (Krebs, 1985). Basically, the system involves a minimum of three proteins and two reactions:
$$ Protein\, + \,nNTP\,---\,Protein - Pn\, + \,nNDP $$
$$ Protein - Pn\, + \,n{{H}_{2}}{\text{O}}\,---\,Protein\, + \,nPi $$
Reaction (1) is catalyzed by protein kinase(s) and reaction (2) by phosphoprotein phosphatase(s). In general NTP is ATP but several protein kinases are today known in which GTP is almost as effective as ATP (Krebs and Beavo, 1979).


Okadaic Acid Glycogen Phosphorylase Dependent Protein Kinase Rabbit Skeletal Muscle Phosphorylase Kinase 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • T. G. Sotiroudis
    • 1
  • V. G. Zevgolis
    • 1
  • A. E. Evangelopoulos
    • 1
  1. 1.Institute of Biological ResearchThe National Hellenic Research FoundationAthensGreece

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