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The Human Type I cGMP-Dependent Protein Kinase Gene

  • Conference paper
Biological Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 52))

Summary

The type I cGMP-dependent protein kinase has been shown to play a crucial role in relaxation of vascular smooth muscle and is believed to mediate its effects via regulation of the calcium levels in the cell. Two isoforms of type I cGMP-dependent protein kinase, designated type Iα and type Iβ have been shown to exist. With exception of the amino terminal part of the molecules the two isoforms are identical. To elucidate which genetic mechanism is responsible for the existence of two isoforms we have undertaken the task of characterizing the human gene(s) for these proteins. Using cDNA probes encoding the type Iβ cGMP-dependent protein kinase (Sandberg et al 1989), 8 exons covering approximately half the coding region have been isolated so far. Several exon/intron splice junctions have been conserved between Drosophila and human cGMP-dependent protein kinase.

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Author information

Authors and Affiliations

  1. Institute of Medical Biochemistry, University of Oslo, P.O.Box 1112, Blindern, N-0317, Oslo 3, Norway

    M. Sandberg, S. Ørstavik & T. Jahnsen

  2. Labor für Klinische Biochemie, Medizinische Univ.-Klinik, University of Würzburg, Josef Schneider Strasse 2, D-8700, Würzburg, Germany

    M. Sandberg, V. Natarajan & S. M. Lohmann

  3. Laboratory for Gene Technology Institute of Pathology Rikshospitalet, University of Oslo, N-0027, Oslo 1, Norway

    V. Natarajan, S. Ørstavik, S. M. Lohmann & T. Jahnsen

Authors
  1. M. Sandberg
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  2. V. Natarajan
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  3. S. Ørstavik
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  4. S. M. Lohmann
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  5. T. Jahnsen
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Editor information

Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Sandberg, M., Natarajan, V., Ørstavik, S., Lohmann, S.M., Jahnsen, T. (1991). The Human Type I cGMP-Dependent Protein Kinase Gene. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_21

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75138-7

  • Online ISBN: 978-3-642-75136-3

  • eBook Packages: Springer Book Archive

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