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Expression of Two Isoforms of the Guanine Nucleotide Binding Protein,Go, IN NG108–15 Neuroglioma Cells

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Book cover Biological Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 52))

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Abstract

Members of a family of guanine nucleotide binding proteins (G-proteins) have been demonstrated to be neccessary to allow transduction of information from hormone-activated cell-surface receptors to effector systems which are either ion channels or enzymes which alter the rate of synthesis of intracellular second messengers [Gilman, 1987, Milligan, 1989]. Each of these G-proteins is a heterotrimer consisting of distinct α, β and γ subunits. A degree of genetic diversity has been noted for both β and γ subunits [Gao et al., 1987, Gautam et al., 1989], but it is at the level of the α subunits where the greatest diversity occurs. Whilst a high degree of homology exists between the individual a subunits, it is believed that the selectivity of transmembrane signalling is defined by the differences between the individual α subunits.

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Authors and Affiliations

  1. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK

    Ian Mullaney & Graeme Milligan

  2. Molecular Pharmacology Group, Department of Pharmacology, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK

    Graeme Milligan

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  1. Ian Mullaney
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Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Mullaney, I., Milligan, G. (1991). Expression of Two Isoforms of the Guanine Nucleotide Binding Protein,Go, IN NG108–15 Neuroglioma Cells. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75138-7

  • Online ISBN: 978-3-642-75136-3

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