G Protein-Coupled Receptors: Structural Basis of Selective Signaling
Animal cells must respond appropriately to multiple hormonal signals. These signals, which may be mutually potentiative or antagonistic, must be integrated to yield appropriate intracellular signals in the form of second messengers, such as cyclic AMP, inositol phosphates, Ca2+, etc. Although receptors are responsible for detecting extracellular signals, signal integration and sorting frequently depend on the activities of GTP-binding transducer proteins known as G proteins.
KeywordsAdrenergic Receptor Intracellular Loop Cytoplasmic Loop Chimeric Receptor Wasp Venom
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- Parker, EM, and Ross, EM (1990) G protein-coupled receptors: Structure and function of signal transducing proteins. In: Current Topics in Membranes and Transport, v 36, T Claudio, Ed, Academic Press, NY pp 131–144Google Scholar