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The T Cell Activation Molecule CD27 Is a Member of the Nerve Growth Factor Receptor Gene Family

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Biological Signal Transduction

Part of the book series: NATO ASI Series ((ASIH,volume 52))

Summary

CD27 is a membrane glycoprotein expressed on human T lymphocytes. Antigen recognition by T cells transiently induces high CD27 RNA and protein levels. This is dependent on intracellular Ca2+ and cAMP concentrations, but not on protein kinase C activation. CD27 belongs to a newly defined gene family, that includes receptors for nerve growth factor and tumor necrosis factor. Homology is primarily located in the N-terminal cysteine-rich domain, thought to be involved in ligand binding. Certain members of this family share a role in induction of neuronal and/or lymphoid cell differentiation and survival. We speculate that CD27 is a receptor for a T cell growth and/or differentiation factor that acts as a progression signal during a late stage of T cell activation.

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Authors and Affiliations

  1. Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Wil A. M. Loenen, Rolien de Jong, Loes A. Gravestein, René A. W. van Lier & Jannie Borst

  2. Division of Clinical Viral Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands

    Rolien de Jong & René A. W. van Lier

Authors
  1. Wil A. M. Loenen
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  2. Rolien de Jong
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  3. Loes A. Gravestein
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  4. René A. W. van Lier
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  5. Jannie Borst
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Editors and Affiliations

  1. Dept. of Pharmacology, Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9041, USA

    Elliott M. Ross

  2. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1991 Springer-Verlag Berlin Heidelberg

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Loenen, W.A.M., de Jong, R., Gravestein, L.A., van Lier, R.A.W., Borst, J. (1991). The T Cell Activation Molecule CD27 Is a Member of the Nerve Growth Factor Receptor Gene Family. In: Ross, E.M., Wirtz, K.W.A. (eds) Biological Signal Transduction. NATO ASI Series, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75136-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-75136-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75138-7

  • Online ISBN: 978-3-642-75136-3

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