T Cell Development in T Cell Receptor Transgenic Mice

  • Horst Blüthmann
  • Michael Steinmetz
  • Harald von Boehmer
Conference paper
Part of the NATO ASI Series book series (volume 38)


During T cell development in the thymus genes coding for the α and β chains of the T cell receptor (TCR) are assembled from the respective gene segments (for review see Kronenberg et al. 1986). Combinatorial joining of different α and β gene segments leads to a diverse spectrum of TCR specificities on developing thymocytes which are positively selected for self-MHC recognition and negatively for self tolerance during further maturation (Fink and Bevan 1978, Zinkernagel et al. 1978). The enormous diversity of the T cell repertoire, however, makes it difficult to follow a T cell with a given specificity during T cell development.


Transgenic Mouse Gamma Delta Alpha Beta Cell Receptor Gene Single Positive Thymocyte 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Horst Blüthmann
    • 1
  • Michael Steinmetz
    • 1
  • Harald von Boehmer
    • 2
  1. 1.Central Research UnitsF. Hoffmann-La Roche & Co. Ltd.BaselSwitzerland
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

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