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T Cell Development in T Cell Receptor Transgenic Mice

  • Horst Blüthmann
  • Michael Steinmetz
  • Harald von Boehmer
Conference paper
Part of the NATO ASI Series book series (volume 38)

Abstract

During T cell development in the thymus genes coding for the α and β chains of the T cell receptor (TCR) are assembled from the respective gene segments (for review see Kronenberg et al. 1986). Combinatorial joining of different α and β gene segments leads to a diverse spectrum of TCR specificities on developing thymocytes which are positively selected for self-MHC recognition and negatively for self tolerance during further maturation (Fink and Bevan 1978, Zinkernagel et al. 1978). The enormous diversity of the T cell repertoire, however, makes it difficult to follow a T cell with a given specificity during T cell development.

Keywords

Transgenic Mouse Gamma Delta Alpha Beta Cell Receptor Gene Single Positive Thymocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Horst Blüthmann
    • 1
  • Michael Steinmetz
    • 1
  • Harald von Boehmer
    • 2
  1. 1.Central Research UnitsF. Hoffmann-La Roche & Co. Ltd.BaselSwitzerland
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

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