Analysis of Autoantigenic Determinants of Thyroid Peroxidase Antigen, Generated Using Polymerase Chain Reaction
Immune reactivity manifests itself in the form of B cell, that is antibody and T cell reactivity. In autoimmune disease, immune reactivity is directed towards particular target antigens (Weetman & McGregor, 1984). It has been difficult to experimentally study a large proportion of autoimmune disease due to the lack of knowledge on the nature of the autoantigen or, in cases where the autoantigen is known, the lack of available purified antigen. This lack of antigen may be due to the difficulty in purifying the material or difficulty in obtaining sufficient human tissue for biochemical purifications.
KeywordsHuman Thyroid Cell Fusion Polypeptide AITD Patient Purify Inclusion Body Autoantigenic Epitope
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