Purification of an Odorant Binding Protein from Human Nasal Mucosa

  • P. Pelosi
  • C. Maremmani
  • A. Muratorio
Part of the NATO ASI Series book series (volume 39)


The nasal mucosa of several mammals contains a protein that binds several odorants with dissociation constants in the micromolar range and is not found anywhere else in the body. This protein, that is very abundant, accounting for up to 1% of total soluble protein in the nasal mucosa, has been first identified and purified from the cow (Pelosi et al.,1982; Bignetti et al.,1985a; Pevsner et al.,1985) and fully characterized both in terms of structure and of binding specificity (Bignetti et al.,1985b, 1987; Cavaggioni et al.,1987; Pelosi and Tirindelli, 1988; Pevsner et al., 1986, 1988b; Topazzini et al., 1985).


Nasal Mucosa Olfactory Receptor Total Soluble Protein Olfactory Mucosa Odorant Binding Protein 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. Pelosi
    • 1
  • C. Maremmani
    • 2
  • A. Muratorio
    • 2
  1. 1.Istituto di Industrie AgrariePisaItaly
  2. 2.Istituto di Clinica NeurologicaPisaItaly

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