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Temporal Patterns of Membrane Potential in the Olfactory Bulb Observed with Intracellular Recording and Voltage-Sensitive Dye Imaging: Early Hyperpolarization

  • J. S. Kauer
  • K. A. Hamilton
  • S. R. Neff
  • A. R. Cinelli
Part of the NATO ASI Series book series (volume 39)

Abstract

Adrian’s (1951, 1956) early work was instrumental in suggesting that changes in the time course of spikes and membrane potentials (temporal patterning) and differences in the degree of activation across cells (spatial patterning) could play roles in encoding characteristics of odorous stimuli. In light of the relatively broad-spectrum responses observed at receptor (Getchell and Shepherd, 1978a,b; Revial et al., 1982, 1983) and olfactory bulb (Kauer, 1974; Meredith and Moulton, 1978; Mair, 1982) levels, it continues to be generally believed that many neurons at each stage in the olfactory pathway are activated by odor stimulation and it is, therefore, this aggregate activity that carries the neural representation of the quality and intensity of the stimulus.

Keywords

Olfactory Bulb Olfactory Nerve Mitral Cell Odor Stimulus Tiger Salamander 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adrian ED (1951) Olfactory discrimination. L’Anee Psychol 50:107–113Google Scholar
  2. Adrian ED (1956) The action of the mammalian olfactory organ. J Laryngol Otol 70:114CrossRefGoogle Scholar
  3. Getchell TV, Shepherd GM (1978a) Responses of olfactory receptor cells to step pulses of odour at different concentrations in the salamander. J Physiol 282:521–540Google Scholar
  4. Getchell TV, Shepherd GM (1978b) Adaptive properties of olfactory receptors analyzed with odour pulses of varying durations. J Physiol 282:541–560Google Scholar
  5. Halasz N, Shepherd GM (1983) Neurochemistry of the vertebrate olfactory bulb. Neurosci 10:579–620CrossRefGoogle Scholar
  6. Hamilton KA, Kauer JS (1985) Intracellular potentials of salamander mitral/tufted neurons in response to odor stimulation. Br Res 338:181–185CrossRefGoogle Scholar
  7. Hamilton KA, Kauer JS (1988) Responses of mitral/tufted cells to orthodromic and antidromic electrical stimulation in the olfactory bulb of the tiger salamander. J Neurophysiol 59:1736–1755PubMedGoogle Scholar
  8. Hamilton KA, Kauer JS (1989) Responses of mitral/tufted cells to odor stimulation in the olfactory bulb of the tiger salamander. J Neurophysiol (in press)Google Scholar
  9. Hamilton KA, Kream RM, Kauer JS (1987) Neurochemical analysis of the salamander olfactory bulb. Chem Senses 12:663 (abst)Google Scholar
  10. Herrick CJ (1948) The Brain of the Tiger Salamander, Univ. of Chicago Press, ChicagoGoogle Scholar
  11. Jastreboff PJ, Pedersen PE, Greer CA, Stewart WB, Kauer JS, Benson TE, Shepherd GM (1984) Specific olfactory receptor populations projecting to identified glomeruli in the rat olfactory bulb. PNAS 81:5250–5254PubMedCrossRefGoogle Scholar
  12. Jourdan F, Duveau A, Astic L, Holley A (1980) Spatial patterns of 2-deoxyglucose uptake in the olfactory bulb of rats stimulated with two different odors. Br Res 188:139–154CrossRefGoogle Scholar
  13. Kauer JS (1974) Response patterns of amphibian olfactory bulb neurones to odour stimulation. J Physiol 243:695–716PubMedGoogle Scholar
  14. Kauer JS (1981) Olfactory receptor cell staining using horseradish peroxidase. Anat Rec 200:331–336PubMedCrossRefGoogle Scholar
  15. Kauer JS (1987) Coding in the olfactory system. In: Finger TE, Silver W (eds) Neurobiology of Taste and Smell. Wiley and Son, New York, pp 205–231Google Scholar
  16. Kauer JS (1988) Real-time imaging of evoked activity in local circuits of the salamander olfactory bulb. Nature 331:166–168PubMedCrossRefGoogle Scholar
  17. Kauer JS, Moulton DG (1974) Responses of olfactory bulb neurones to odour stimulation of small nasal areas in the salamander. J Physiol 243:717–737PubMedGoogle Scholar
  18. Kauer JS, Shepherd GM (1975) Olfactory stimulation with controlled and monitored step pulses of odor. Br Res 85:108–113CrossRefGoogle Scholar
  19. MacKay-Sim A, Shaman P, Moulton DG (1982) Topographic coding of olfactory quality: Odorant specific patterns of epithelial responsivity in the salamander. J Neurophys 48:584–596Google Scholar
  20. Mair RG (1982) Response properties of rat olfactory bulb neurones. J Physiol 326:341–359PubMedGoogle Scholar
  21. Meredith M, Moulton DG (1978) Patterned response to odor in single neurones of goldfish olfactory bulb: influence of odor quality and other stimulus parameters. J Gen Physiol 71:615–643PubMedCrossRefGoogle Scholar
  22. Mori K, Nowycky MC, Shepherd GM (1981a) Electrophysiological analysis of mitral cells in the isolated turtle olfactory bulb. J Physiol 314:281–294PubMedGoogle Scholar
  23. Mori K, Nowycky MC, Shepherd GM (1981b) Analysis of synaptic potentials in mitral cells in isolated turtle olfactory bulb. J Physiol 314:295–309PubMedGoogle Scholar
  24. Mori K, Nowycky MC, Shepherd GM (1981c) Analysis of a long-duration potentials in mitral cells of the isolated turtle olfactory bulb. J Physiol 314:311–320PubMedGoogle Scholar
  25. Revial MF, Sicard A, Duchamp A, Holley A (1982) New studies on odour discrimination in the frog’s olfactory receptor cells. I. Experimental results. Chem Senses 7:175–190CrossRefGoogle Scholar
  26. Revial MF, Sicard A, Duchamp A, Holley A (1983) New studies on odour discrimination in the frog’s olfactory receptor cells. II. Mathematical analysis of electrophysiological responses. Chem Senses 8:179–190CrossRefGoogle Scholar
  27. Sharp FR, Kauer JS, Shepherd GM (1975) Local sites of activity-related glucose metabolism in rat olfactory bulb during odor stimulation. Br Res 98:596–600CrossRefGoogle Scholar
  28. Shepherd GM (1963) Neuronal systems controlling mitral cell excitability. J Physiol 168:101–117PubMedGoogle Scholar
  29. Stewart WB, Kauer JS, Shepherd GM (1979) Functional organization of rat olfactory bulb analyzed by the 2-deoxyglucose method. J Comp Neurol 185:715–734.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. S. Kauer
    • 1
  • K. A. Hamilton
    • 1
  • S. R. Neff
    • 1
  • A. R. Cinelli
    • 1
  1. 1.Departments of Neurosurgery and Anatomy & Cell Biology, and the Section Of NeuroscienceNew England Medical Center/Tufts Medical SchoolBostonUSA

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