Abstract
Over the last five years it has become feasible to study the olfactory transduction process by the patch-clamp technique. Valuable contributions have come from Maue and Dionne (1987), Firestein and Werblin (1987,1989), Frings and Lindemann (1988), Zufall et al.(1989), Schild (1989), Schmiedel-Jacob et al.(1989), and Trotier (1986). From these studies we now know more about the ionic channels and the whole-cell voltage-gated currents present in these cells, though their physiological role has not been clarified in detail.
Supported by the Deutsche Forschungsgemeinschaft, SFB 236/A19
JAD was on sabbatical leave from the Dept. of Physiology, Virginia Commonwealth University
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References
Firestein S, Werblin F (1987) Gated currents in isolated olfactory receptor neurons of the larval tiger salamander. Proc.Natl.Acad.Sci.USA 84:6292–6296
Firestein S, Werblin F (1989) Odor-induced membrane currents in vertebrate olfactory receptor neurons. Science 244:79–82
Frings S, Lindemann B (1988) Odorant response of isolated olfactory receptor cells is blocked by amilorid. J.Membrane Biol. 105:233–243
Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85–100
Joshi et al.(1987) Spectrophotometric determination of cation concentrations in olfactory mucus. Neuroscience Letters 82:321–326
Kuba K, Nishi S (1976) Rhythmic hyperpolarizations and depolarizations of sympathetic ganglion cells induced by caffeine. J.Neurophysiol. 39:547–563
Lancet D (1986) Vertebrate olfactory reception. In: Cowan WM (ed) Annual Reviews of Neuroscience, 9. Annual Reviews, Palo Alto 329–355
Maue RA, Dionne VE (1987) Patch-clamp studies of isolated mouse olfactory receptor neurons. J.Gen.Physiol. 90:95–125
Persaud KC, Heck GL, DeSimone SK, Getchell TV, DeSimone JA (1988) Ion transport across the frog olfactory mucosa: the action of cyclic nucleotides on the basal and odorant-stimulated states. Biochim.Biophys.Acta 944:49–62
Restrepo D, Bruch RC (1989) Stimulus amino acids elicit rapid increase in intracellular calcium in dissociated olfactory neurons. Achems XI:150
Schild D (1989) Whole-cell currents in olfactory receptor cells of Xenopus laevis. Exp.Brain Res. 78:223–232
Schmiedel-Jacob I, Anderson PAV, Ache BW (1989) Whole-cell recordings from lobster olfactory receptor cells: responses to current and odor stimulation. J.Neurophysiol. 61:994–1000
Trotier D (1986) A patch-clamp analysis of membrane currents in salamander olfactory receptor cells. Pflügers Arch. 407:589–595
Zufall F, Stengl M, Hildebrand JG, Hatt H (1989) A patch clamp study of cultured olfactory receptor neurons from manduca sexta. Proceedings of the 17-th Göttingen Neurobiology Conference:75
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Schild, D., DeSimone, J.A., Hellwig, S. (1990). Excitation and adaptation of frog olfactory receptor neurones upon stimulation with second messengers and natural odorants. In: Schild, D. (eds) Chemosensory Information Processing. NATO ASI Series, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75127-1_2
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DOI: https://doi.org/10.1007/978-3-642-75127-1_2
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