The Neurobiology of Endogenous Pyrogens

  • C. M. Blatteis
Conference paper

Abstract

That a link exists between the central nervous (CNS) and immune systems is no longer disputed. Thus, CNS lesions and sundry hormonal and autonomic manipulations have demonstrated that, besides the many mediators that provide regulatory signals within the immune system, the nervous system plays an important modulatory role. Connections from the autonomic nervous system to lymphoid tissue have been described, and neuroendocrine influences on immunity are well documented. As the hypothalamus is central to the control of both autonomie and neuroendocrine outflows, it is also the target of signals generated by the immune system. For example, changes in the electrical activity of neurons in discrete hypothalamic areas have been recorded during immunogenesis. Also, the peripheral and/or central administration of several factors produced by the immune system elicits responses pathognomonic of infectious disease, e.g., fever, increased plasma levels of acute-phase reactants, and enhanced slow-wave sleep. Hence, these immune products are presumptive mediators of signal transmission from the immune to the nervous system, possibly functioning as the afferent part of a neuroimmunomodulatory feedback system. Indeed, recent evidence suggests that interleukin-1 (IL1), one such product of immunocompetent cells, may mediate the secretion of pituitary adrenocorticotrophic hormone. Subsequently released adrenal glucocorticoids may then act to suppress the further production of IL1. These aspects of neural-immune interaction have been reviewed recently (Weigent and Blalock 1987; Saphier et al. 1987; Besedovsky and Del Rey 1987; Felten et al. 1987; Roszman et al. 1985; Cotman et al. 1987).

Keywords

Interferon Prostaglandin Norepinephrine Glucocorticoid Meningitis 

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References

  1. Ahmed MS, Llanos QJ, Dinarello CA Blatteis CM (1985) Interleukin-1 reduces Opioid binding in guinea pig brain. Peptides 6:1149–1154.PubMedCrossRefGoogle Scholar
  2. Ahokas RA, Seydoux J, Llanos QJ, Mashburn TA Jr, Blatteis CM (1985) Hypothalamic Opioids and the acute-phase glycoprotein response in guinea pigs. Brain Res Bull 15:603–608.PubMedCrossRefGoogle Scholar
  3. Banet M, Brandt S (1987) The effect of a fever-like response on the secondary antibody response of the rat. Brain Res Bull 18:265–267.PubMedCrossRefGoogle Scholar
  4. Baumann H, Richards C, Gauldie J (1987) Interaction between hepatocyte-stimulating factors, interleukin-1 and glucocorticoids for regulation of acute-phase plasma proteins in human HepG2 cells. J Immunol 139:4122–4128.PubMedGoogle Scholar
  5. Beeson PB (1948) Temperature-elevating effect of a substance obtained from polymorphonuclear leukocytes. J Clin Invest 27:524.PubMedGoogle Scholar
  6. Bell RC, Dao TK, Feng J, Lipton JM (1987) Central administration of melanocyte stimulating hormone (MSH) inhibits fever, serum CRP increases and neutrophilia caused by interleukin-1 in rabbits of different ages. Fed Proc 46:682.Google Scholar
  7. Bell RC, Lipton JM (1987) Pulsatile release of antipyretic neuropeptide α-MSH from septum of rabbit during fever. Am J Physiol 252:R1152–R1157.PubMedGoogle Scholar
  8. Bennett TL, Beeson PB (1953) Studies on the pathogenesis of fever. II. Characterization of feverproducing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates. J Exp Med 98:493–508.PubMedCrossRefGoogle Scholar
  9. Berkenbosch F, Van Ders J. Del Rey A, Tilders F, Besedovsky HO (1987) Corticotropin releasing factor-producing neurons in the rat activated by interleukin-1. Science 238:524–526.PubMedCrossRefGoogle Scholar
  10. Bernardini GL, Richards DB, Lipton JM (1985) Antipyretic effect of centrally administered CRF. Peptides 5:57–59.CrossRefGoogle Scholar
  11. Bernheim HA (1986) Is Prostaglandin E2 involved in the pathogenesis of fever? Effects of interleukin-1 on the release of Prostaglandins. Yale J Biol Med 59:151–158.PubMedGoogle Scholar
  12. Bernton EW, Beach JE, Holaday JW, Smallridge RC, Fein H (1987) Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238:519–521.PubMedCrossRefGoogle Scholar
  13. Besedovsky HO, Del Rey A (1987) Neuroendocrine and metabolic responses induced by interleukin-1. J Neurosci Res 18:172–178.PubMedCrossRefGoogle Scholar
  14. Besedovsky HO, Del Rey AE, Sorkin E (1985) Immune-neuroendocrine interactions. J Exp Immunol 135:7505–7545.Google Scholar
  15. Besedovsky H, Del Rey A, Sorkin E, Dinarello CA (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652–654.PubMedCrossRefGoogle Scholar
  16. Beutler B, Cerami A (1988) Tumor necrosis, cachexia, shock, and inflammation: A common mediator. Ann Rev Biochem 57:505–518.PubMedCrossRefGoogle Scholar
  17. Billiau A, Heine JW, Van Damme J, Heremans H, DeSomer P (1980) Tolerability of pure fibroblast interferon in man. Ann NY Acad Sci 350:374–375.PubMedCrossRefGoogle Scholar
  18. Blalock JE, Smith EM (1981) Human leukocyte interferon (HuIFNα); potent endorphin-like Opioid activity. Biochem Biophys Res Commun 101:472–478.PubMedCrossRefGoogle Scholar
  19. Blalock JE, Smith EM (1985) A complete regulatory loop between the immune and neuroendocrine systems. Fed Proc 44:108–111.PubMedGoogle Scholar
  20. Blatteis CM (1988) Neural mechanisms in the pyrogenic and acute-phase responses to interleukin-I. Int J Neurosci 38:223–232.PubMedCrossRefGoogle Scholar
  21. Blatteis CM, Ahokas RA, Dinarello CA, Ungar AL (1987a) Thermal and plasma Cu responses of guinea pigs to intrapreoptically injected rIL1, rIL2, rIFNα, and rTNFα. Fed Proc 46:683.Google Scholar
  22. Blatteis CM, Bealer SL, Hunter WS, Llanos QJ, Ahokas RA, Mashburn TA Jr (1983) Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res Bull 11:519–526.PubMedCrossRefGoogle Scholar
  23. Blatteis CM, Hales JRS, McKinley MJ, Fawcett AA (1987b) Role of the anteroventral third ventricle in fever in sheep. Can J Physiol Pharmacol 65:1255–1260.PubMedCrossRefGoogle Scholar
  24. Blatteis CM, Howell RD, Quan N (1989) Effects of naloxone (NAL) and indomethacin (INDO) on the fevers induced by interferon α2 (IFN), tumor necrosis factor (TNF), and lipopolysaccharides (LPS). FASEB J 3:A679.Google Scholar
  25. Blatteis CM, Hunter WS, Llanos-Q J, Ahokas RA, Mashburn TA Jr (1984) Activation of acute-phase responses by intrapreoptic injections of endogenous pyrogen in guinea pigs. Brain Res Bull 12:689–695.PubMedCrossRefGoogle Scholar
  26. Blatteis CM, Mashburn TA Jr, Llanos-Q J, Ahokas RA (1985) Thermal and acute phase glycoprotein responses of guinea pigs to intrapreoptically injected PGD2, PGFα2, and PGI2. Fed Proc 44:438.Google Scholar
  27. Bocci V (1981) Production and role of interferon in physiological conditions. Biol Rev 56:49–85.PubMedCrossRefGoogle Scholar
  28. Bornstein DL (1982) Leukocytic pyrogen: A major mediator of the acute-phase reaction. Ann NY Acad Sci 389:323–337.PubMedCrossRefGoogle Scholar
  29. Boulant JA, Scott IM (1986) Comparison of Prostaglandin E2 and leukocytic pyrogen on hypothalamic neurons in tissue slice. In: Cooper KE, Lomax P, Schönbaum E, Veale WL (eds) Homeostasis and thermal stress. Karger, Basel, pp 78–80.Google Scholar
  30. Brandt S, Banet M (1984) The effect of hypothalamic temperature on the immune response of the rat. Brain Res Bull 13:247–251.PubMedCrossRefGoogle Scholar
  31. Breder CD, Dinarello CA, Saper CB (1988) Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240:321–324.PubMedCrossRefGoogle Scholar
  32. Breder CD, Saper CB (1988) Tumor necrosis factor immunoreactive innervation in the mouse brain. Soc Neurosci Abstr 14:1280.Google Scholar
  33. Cannon JG, Tatro JB, Reichlin S, Dinarello CA (1986) α-Melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin-1. J Immunol 137:232–236.Google Scholar
  34. Chowers I, Hammel HT, Eisenman J, Abrams RM, McCann SM (1966) A comparison of the effects of environmental and preoptic heating and pyrogen on plasma cortisol levels. Am J Physiol 210:606–610.PubMedGoogle Scholar
  35. Chowers I, Hammel HT, Stromme SB, McCann SM (1964) Comparison of effect of environmental and preoptic cooling on plasma cortisol levels. Am J Physiol 207:577–582.PubMedGoogle Scholar
  36. Coceani E, Bishai I, Lees J, Sisko S (1986) Prostaglandin E2 and fever: A continuing debate. Yale J Biol Med 59:169–174.PubMedGoogle Scholar
  37. Coceani F, Lees J, Dinarello CA (1988) Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res 446:245–250.PubMedCrossRefGoogle Scholar
  38. Coombes RC, Rothwell NJ, Shah P, Stock M (1988) Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat. Biosci Rep 7:791–799.CrossRefGoogle Scholar
  39. Cooper KE (1987) The neurobiology of fever: Thoughts on recent developments. Ann Rev Neurosci 10:297–324.PubMedCrossRefGoogle Scholar
  40. Cornell RP (1987a) Central administration of interleukin-1 elicits hyperinsulinemia in rats. Circ Shock 21:293.Google Scholar
  41. Cornell RP (1987b) Inhibition of interleukin-1-induced hyperinsulinemia by Prostaglandin but not vagal blockade in rats. J Leukocyte Biol 42:596.Google Scholar
  42. Cotman CW, Brinton RE, Galaburda A, McEwen B, Schneider DM (1987) The neuroimmuno-endocrine connection. Raven, New York.Google Scholar
  43. Cowens PG, Wolf BA, Unanue ER, Lacy PE, McDaniel ML (1987) Interleukin-1 is a potent modulator of insulin secretion from isolated rat islets of Langerhans. Diabetes 36:963–970.CrossRefGoogle Scholar
  44. Del Rey A, Besedovsky H (1987) Interleukin-1 affects glucose homeostasis. Am J Physiol 253:R794–R798.PubMedGoogle Scholar
  45. Dinarello CA (1986) Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin). Year Immunol 2:68–89.PubMedGoogle Scholar
  46. Dinarello CA (1988) Biology of interleukin-1. FASEB J 2:108–115.PubMedGoogle Scholar
  47. Dinarello CA, Bernheim HA, Duff CW, Le HV, Nagabhushan TL, Hamilton NC, Coceani F (1984) Mechanisms of fever induced by recombinant human interferon. J Clin Invest 74:906–913.PubMedCrossRefGoogle Scholar
  48. Dinarello CA, Cannon JG, Wolff SM (1988) New concepts on the pathogenesis of fever. Rev Infect Dis 10:168–169.PubMedCrossRefGoogle Scholar
  49. Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA Jr, O’Connor JV (1986) Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-l. J Exp Med 163:1433–1450.PubMedCrossRefGoogle Scholar
  50. Dinarello CA, Wiener P, Wolff SM (1978) Radiolabeling and disposition in rabbits of purified human leukocytic pyrogen. Clin Res 26:522A.Google Scholar
  51. Dunn AJ (1988) Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism paralleling the increased plasma corticosterone. Life Sci 43:429–435.PubMedCrossRefGoogle Scholar
  52. Eisenman JS (1982) Electrophysiology of the anterior hypothalamus. Thermoregulation and fever. In: Milton AS (ed) Pyretics and antipyretics. Springer, Berlin Heidelberg New York, pp 187–217.CrossRefGoogle Scholar
  53. Farrar WL, Hill JM, Harel-Bellan A, Vinocour M (1987b) The immune logical brain. Immunol Rev 100:361–378.PubMedCrossRefGoogle Scholar
  54. Farrar WL, Kilian PL, Ruff MR, Hill JM, Pert CB (1987a) Visualization and characterization of interleukin-1 receptors in brain. J Immunol 139:459–463.PubMedGoogle Scholar
  55. Feiten DL, Feiten SY, Bellinger DL, Carlson SL, Ackerman KD, Maddin KS, Olschowka JA, Livnat S (1987) Noradrenergic sympathetic neural interactions with the immune system. Structure and function. Immunol Rev 100:255–260.Google Scholar
  56. Feng JD, Dao T, Lipton JM (1987) Effects of preoptic microinjections of α-MSH on fever and normal temperature control in rabbits. Brain Res Bull 18:473–477.PubMedCrossRefGoogle Scholar
  57. Fontana A, Kristensen F, Dubs R, Gemsa D, Weber E (1985) Production of Prostaglandin E and an interleukin-1-like factor by cultured astrocytes and C6 glioma cells. J Immunol 129:2413–2419.Google Scholar
  58. Fontana A, Weber E, Dayer JM (1986) Synthesis of interleukin-1/endogenous pyrogen in the brain of endotoxin-treated mice. Step in fever induction? J Immunol 133:1696–1698.Google Scholar
  59. Gauldie J, Lamontagne L, Stadnyk A (1985) The acute-phase response in infectious disease. Surv Syn Pathol Res 4:126–151.Google Scholar
  60. Gauldie J, Richards C, Marnish D, Lansdorp P, Baumann H (1987) Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute-phase protein response in liver cells. Proc Nat Acad Sci USA 84:7251–7255.PubMedCrossRefGoogle Scholar
  61. Geiger T, Andus T, Klapproth J, Hirano T, Kishimoto T, Heinrich PC (1988) Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol 18:717–721.PubMedCrossRefGoogle Scholar
  62. George DT, Abeles FB, Mapes CA, Sobocinski PE, Zenser TV, Powanda MC (1977) Effect of leukocytic endogenous mediator on endocrine pancreas secretory responses. Am J Physiol 233:E240–E245.PubMedGoogle Scholar
  63. Gery I, Gershon RK, Waksman RM (1972) Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. J Exp Med 136:128–142.PubMedCrossRefGoogle Scholar
  64. Giulian D, Baker TJ, Shih LN, Lachman LB (1986) Interleukin-1 of the central nervous system is produced by ameboid microglia. J Exp Med 164:594–604.PubMedCrossRefGoogle Scholar
  65. Gordon AM, Koj A (eds) (1985) The acute-phase response to injury and infection. The roles of interleukin-1 and other mediators. Elsevier, New York.Google Scholar
  66. Gordon CJ, Heath JE (1980) Effects of Prostaglandin E on the activity of thermosensitive and insensitive single units in the preoptic/anterior hypothalamus of anesthetized rabbits. Brain Res 183:113–121.PubMedCrossRefGoogle Scholar
  67. Hori Y, Blatteis CM, Nasjletti A (1987) Production of PGE2 by brain slices stimulated with various thermoactive agents. Fed Proc 46:683.Google Scholar
  68. Houssiau FA, Bukasa K, Sindie CJM, Van Damme J, Van Snich J (1988) Elevated levels of the 26K human hybridoma growth factor (interleukin-6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 71:320–323 (1987).PubMedGoogle Scholar
  69. Hunter WS, Blatteis CM, Llanos-Q J, Mashburn TA Jr, Ahokas RA (1987) Thermal stimulation of the hypothalamus does not evoke the acute-phase reaction. Brain Res Bull 19:69–74.PubMedCrossRefGoogle Scholar
  70. Kampschmidt RF (1978) Leukocytic endogenous mediator. J Reticuloendothel Soc 23:287–297.PubMedGoogle Scholar
  71. Katsuura G, Arimura A (1988) Interleukin-1 beta messenger of the immune signal to the neuroendocrine system may act primarily on the hypothalamus: Presence of its receptor in the hypothalamus, but not in the pituitary of the rat. Endocrinology 122Suppl:132.Google Scholar
  72. Katsuura G, Koves K, Gottschall PE, Arimura A (1988) The Organum vasculosum lamina terminalis (OVLT) and the preoptic anterior hypothalamus area (POA) are primary sites for interleukin-l-induced ACTH release. Soc Neurosci Abstr 14:756.Google Scholar
  73. Koj A, Gordon AH, Gauldie J (1988) An alternative regulatory pathway of the acute-phase response: The role of fibroblast-derived interferon-β2. Experientia 44:9–10.PubMedCrossRefGoogle Scholar
  74. Krueger JM, Dinarello CA, Shoham S, Davenne D, Walter J, Kubillus S (1987) Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol 9:23–30.PubMedCrossRefGoogle Scholar
  75. Krueger JM, Toth LA, Cady AB, Johannsen L, Obal F Jr (1988) Immunomodulation and sleep. In: Inoué S, Schneider-Helmert D (eds) Sleep peptides: Basic and clinical approaches. Springer, Berlin Heidelberg New York, pp 95–129.Google Scholar
  76. Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L (1984) Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 246:994–999.Google Scholar
  77. Le J, Vilcek J (1987) Biology of disease. Tumor necrosis factor and interleukin-1. Cytokines with multiple overlapping biological activities. Lab Invest 56:234–248.PubMedGoogle Scholar
  78. Lee SW, Tsou AP, Chan H, Thomas J, Petrie K, Engui EM, Allison AC (1988) Glucocorticoids selectively inhibit the transcription of the interleukin-1β gene and decrease the stability of interleukin-1β mRNA. Proc Natl Acad Sci USA 85:1204–1208.PubMedCrossRefGoogle Scholar
  79. Lipton JM (1980) Central inactivation of endogenous pyrogens. In: Lipton JM (ed) Fever. Raven, New York, pp 71–80.Google Scholar
  80. Lipton JM (1985) Antagonism of IL-1 fever by the neuropeptide β-MSH. In: Kluger MJ, Oppenheim JJ, Powanda ML (eds) The physiologic, metabolic and immunologic actions of interleukin-1. Liss, New York, pp 121–132.Google Scholar
  81. Mashburn TA Jr, Ahokas RA, Blatteis CM (1986) Thermal and acute-phase responses of guinea pigs to intrapreoptic injections of leukotrienes. Brain Res 34:185–191.Google Scholar
  82. McCarthy DO, Kluger MJ, Vander AJ (1986) Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats. Physiol Behav 36:745–749.PubMedCrossRefGoogle Scholar
  83. McCarthy DO, Kluger MJ, Vander AJ (1987) Suppression of food intake during infection: Is interleukin-1 involved? Am J Clin Nutr 42:1179–1182.Google Scholar
  84. Milton AS (1982) Prostaglandins in fever and the mode of action of antipyretic drugs. In: Milton AS (ed) Pyretics and antipyretics. Springer, Berlin Heidelberg New York Tokyo, pp 257–303.CrossRefGoogle Scholar
  85. Mitchell D, Laburn HP, Cooper KE, Hellon RF, Cranston WI, Townsend Y (1986) Is Prostaglandin E2 the neural mediator of the febrile response? The case against a proven obligatory role. Yale J Biol Med 59:159–168.PubMedGoogle Scholar
  86. Mizel SB (1982) Interleukin-1 and T-cell activation. Immunol Rev 63:51–72.PubMedCrossRefGoogle Scholar
  87. Morimoto A, Murakami N, Myogen T, Takada M, Teshigori S, Watanabe T (1987b) Separate mechanisms inside and outside the blood-brain barrier inducing metabolic changes in febrile rabbits. J Physiol (Lond) 392:637–649.Google Scholar
  88. Morimoto A, Murakami N, Takada M, Teshigori S, Watanabe T (1987a) Fever and acute-phase responses induced in rabbits by human recombinant interferon-γ. J Physiol (Lond) 391:209–218.Google Scholar
  89. Murphy MT, Koenig JI, Lipton JM (1983) Changes in central concentration of β-endorphin in fever. Fed Proc 42:464.Google Scholar
  90. Nakashima T, Hori T, Kuriyama K, Matsuda T (1988) Effects of interferon-α on the activity of preoptic thermosensitive neurons in tissue slices. Brain Res 454:361–367.PubMedCrossRefGoogle Scholar
  91. Oomura Y, Plata-Salaman CR, Nemoto S, Niijima A, Matsumoto I (1987) 2-Buten-4-olide, tumor necrosis factor and interleukin-1β acting as feeding suppressants. Soc Neurosci Abstr 13:464.Google Scholar
  92. Opp MR, Obal F Jr, Krueger JM (1988) Effects of αMSH on sleep, behavior, and brain temperature: Interactions with IL1. Am J Physiol 255:R914–R922.PubMedGoogle Scholar
  93. O’Rourke ST, Rudy TA (1984) Intracerebroventricular and preoptic injections of leukotrienes C4, D4, and E4 in the rat. Lack of a febrile effect. Brain Res 295:283–288.PubMedCrossRefGoogle Scholar
  94. Perlmutter DH, Dinarello CA, Punsal PI, Colten HR (1986) Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest 78:1349–1354.PubMedCrossRefGoogle Scholar
  95. Quan N, Van Huysse J, Howell RD, Ungar A, Blatteis CM (1988) Hyperthermia evoked by intrapreoptic administration of pyrogen-free saline (PFS): Abolition by microdialysis. FASEB J 2:A1531.Google Scholar
  96. Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR (1985) Pretranslational modulation of acute-phase hepatic protein synthesis by murine recombinant interleukin-1 and purified human IL1. J Exp Med 162:930–942.PubMedCrossRefGoogle Scholar
  97. Reinke R, Feigelson P (1985) Rat α1,-acidglycoprotein. Gene sequence and regulation by glucocorticoids in transfected L-cells. J Biol Chem 260:4397–4403.PubMedGoogle Scholar
  98. Rettori V, Jurcovicova J, McCann SM (1987) Central action of interleukin-1 in altering the release of TSH, growth hormone, and prolactin in the male rat. J Neurosci Res 18:179–183.PubMedCrossRefGoogle Scholar
  99. Rivier C (1988) Symposium: Interleukin-1: Immune and neural modulator. Soc Neurosci Abstr 14:1.Google Scholar
  100. Rothwell NJ (1989) CRF is involved in the pyrogenic and thermogenic effects of interleukin-1β in the rat. Am J Physiol 266:E111–E115.Google Scholar
  101. Rothwell NJ (1988b) Central effects of TNFα on thermogenesis and fever in the rat. Biosci Rep 8:345–352.PubMedCrossRefGoogle Scholar
  102. Roszman TL, Jackson JC, Cross RJ, Titus MJ, Markesbery WR, Brooks WH (1985) Neuroanatomic and neurotransmitter influences on immune function. J Immunol 135:7695–7725.Google Scholar
  103. Sacco NA, Kordyban MA, McCulla EA, Yelich MR, Filkins JP (1987) Glucoregulatory effects of human natural interleukin-1. Circ Shock 21:362.Google Scholar
  104. Saphier D, Abramsky O, Mor G, Ovadia H (1987) Neurophysiological correlate of an immune response. Ann NY Acad Sci 496:354–359.PubMedCrossRefGoogle Scholar
  105. Saphier D, Feldman S (1986) Effects of stimulation of the preoptic area on hypothalamic paraventricular nucleus unit activity and corticosterone secretion in freely moving rats. Neuroendocrinology 42:167–173.PubMedCrossRefGoogle Scholar
  106. Sapolsky C, Rivier C, Yamamoto G, Plotsky P, Vale W (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin releasing factor. Science 238:522–524.PubMedCrossRefGoogle Scholar
  107. Schoener EP, Wang SC (1976) Effects of locally administered Prostaglandin E1 on anterior hypothalamic neurons. Brain Res 117:157–162.PubMedCrossRefGoogle Scholar
  108. Scott IM, Fertel RM, Boulant JA (1987) Leukocytic pyrogen effects on Prostaglandins in hypothalamic tissue slices. Am J Physiol 253:R71–R76.PubMedGoogle Scholar
  109. Shibata M, Blatteis CM (1988) Neuronal responses to recombinant (r) IL-1β, rIFNα2 and rTNFα in slices from guinea pig preoptic area (PO). FASEB J 2:A1531.Google Scholar
  110. Shibata M, Blatteis CM, Krueger JM, Obal F Jr, Opp M (1989) Pyrogenic, inflammatory, and somnogenic responses to cytokinesis: Differential modes of action. In: Lomax P, Schönbaum E (eds) Thermoregulation: Research and clinical applications. Karger, Basel, pp 69–73.Google Scholar
  111. Shoham S, Blatteis CM, Krueger JM (1988) Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever. Brain Res 416:396–399.Google Scholar
  112. Shoham S, Davenne D, Cady A, Dinarello CA, Krueger JM (1987) Recombinant tumor necrosis factor and interleukin-1 enhance slow-wave sleep in rabbits. Am J Physiol 253:R142–R149.PubMedGoogle Scholar
  113. Sobrado J, Moldawer LL, Bistrian BR, Dinarello CA, Balckburn G (1983) Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin-1) or endotoxin. Infect Immunol 42:997–1005.Google Scholar
  114. Socher SH, Friedman A, Martinez D (1988) Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice. J Exp Med 167:1957–1962.PubMedCrossRefGoogle Scholar
  115. Spinas GA, Mandrup-Poulsen T, Molvig J, Baek L, Bendtzen K, Dinarello CA, Nerup J (1986) Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans. Acta Endocrinol 13:551–558.Google Scholar
  116. Stitt JT (1985) Evidence for the involvement of the Organum vasculosum laminae terminalis in the febrile response of rabbits and rats. J Physiol (Lond) 368:501–511.Google Scholar
  117. Stitt JT (1986) Prostaglandin E as the neural mediator of the febrile response. Yale J Biol Med 59:137–149.PubMedGoogle Scholar
  118. Stitt JT, Hardy J (1975) Microelectrophoresis of PGE1 onto single units in rabbit hypothalamus. Am J Physiol 229:240–245.PubMedGoogle Scholar
  119. Tocco RJ, Kahn LL, Kluger MJ, Vander AJ (1983) Relationship of trace metals to fever during infection: Are Prostaglandins involved? Am J Physiol 244:R368–R373.PubMedGoogle Scholar
  120. Van Damme J, Billiau A (1987) Identification of the human 26-kD protein, interferon beta-2, as a B-cell hybridoma/plasmacytoma growth factor induced by interleukin-1 and tumor necrosis factor. J Exp Med 165:914–919.PubMedCrossRefGoogle Scholar
  121. Uehara A, Gillis S, Arimura A (1987) Effects of interleukin-1 on hormone release from normal rat pituitary cells in primary culture. Neuroendocrinology 45:343–347.PubMedCrossRefGoogle Scholar
  122. Walter J, Davenne D, Shoham S, Dinarello CA, Krueger JM (1986) Brain temperature changes coupled to sleep states persist during interleukin-1-enhanced sleep. Am J Physiol 250:R96–R103.PubMedGoogle Scholar
  123. Walter J, Krueger JM, Meyers P, Dinarello CA (1984) Interleukin-1-induced slow wave sleep and fever: Separation of responses. Soc Neurosci Abstr 10:147.Google Scholar
  124. Watanabe T, Morimoto A, Murakami N (1987) Effects of PGE2 on preoptic and anterior hypothalamic neurons using brain slice preparations. J Appl Physiol 63:918–922.PubMedGoogle Scholar
  125. Weigent DA, Blalock JE (1987) Interactions between the neuroendocrine and immune system. Common hormones and receptors. Immunol Rev 100:79–108.PubMedCrossRefGoogle Scholar
  126. Wei K, Dowing J, Taylor M, Elizondo R (1987) The effect of interferon on temperature regulation. Fed Proc 46:682.Google Scholar
  127. Zimmer JA, Lipton JM (1981) Central and peripheral injections of ACTH (1–24) reduce fever in adrenalectomized rabbits. Peptides 2:413–417.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. M. Blatteis
    • 1
  1. 1.Department of Physiology, and BiophysicsMemphisUSA

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