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Prognosefaktoren für die Strahlentherapie

  • Conference paper
Therapie des Zervixkarzinoms

Zusammenfassung

Aus der Rückschau brauchbare Vorhersagen für die heutige Behandlung abzuleiten, d. h. aus den Fehlern der Vergangenheit für die Gegenwart zu lernen, war noch nie einfach, zumal Begriffe wie Risiko oder Prognose mit der modernen Magie von Zahlen nicht umfassend zu definieren sind. Das Strahlen- oder das Operationsrisiko mit Zahlen oder Prozentangaben zu erfassen, ist besonders schwierig, da Können und Leistung, d.h. Kenntnisse, Geschicklichkeit und Erfahrungen einzelner Operateure oder Strahlentherapeuten nicht zu vergleichen sind. In erster Linie interessiert die gemeinsame Leistung einer Klinik oder eines Behandlungszentrums mit möglichst großen Patientengruppen. Prognosefaktoren gelten jedoch nur für die jeweilige Behandlungsmethode, so daß einige Prognosefaktoren nach Operation nicht ohne weiteres auf die Strahlentherapie zu übertragen sind. Viele Veröffentlichungen gehen zwar bisher davon aus, daß Prognosefaktoren für alle Behandlungsmethoden Gültigkeit haben [5]. Prognosefaktoren sollten jedoch in Zukunft getrennt nach Operation oder Bestrahlung aufgelistet werden, um daraus den für die Einzelpatientin optimalen Therapieweg (Individualisierung der Strahlentherapie) [33] zu finden.

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Literatur

  1. Adcock LL, Pothish RA, Julian TM, Okagaki T, Prem KA, Twiggs LB, Savage JZ (1984) Carcinoma of the cervix, FIGO stage I b: Treatment failures. Gynecol Oncol 18: 218–225

    Article  PubMed  CAS  Google Scholar 

  2. Ashby MA, Samales E (1987) Invasive carcinoma of the cervix in young women: Clinical data and prognostic features. Radiat Oncol 10: 174–176

    Google Scholar 

  3. Baltzer J, Koepcke W, Lohe KJ, Ober KG, Zander J (1982) Age and 5-year survival rates in patients with operated carcinoma of the cervix. Gynecol Oncol 14: 220–224

    Article  PubMed  CAS  Google Scholar 

  4. Benstead K, Cowie VJ, Blair V, Hunter RD (1986) Stage III carcinoma of cervix. The importance of increasing age and extent of parametrial infiltration. Radiat Oncol 5: 271–276

    Article  CAS  Google Scholar 

  5. Brady LW, Perez CA, Badwinek JM (1986) Failure patterns in gynecologic cancer. Int J Radiat Oncol Biol Phys 122: 549

    Google Scholar 

  6. Dargent D, Frobert JL, Beau G (1988) V factor and T factor (FIGO classification) in the assessment of cervix cancer prognosis: The risk of lymph node spread. Gynecol Oncol 22: 15–22

    Article  Google Scholar 

  7. Evans JC, Bergsjo P (1965) The influence of anaemia on the results of radiotherapy in carcinoma of the cervix. Radiology 84: 709–717

    PubMed  CAS  Google Scholar 

  8. Girinski T, Pejovic-Leufant MH, Bourhis J et al. (1989) Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: results of a retrospectic study of 386 patients. Int J Radiat Oncol Biol Phys 16: 37–42

    Article  PubMed  CAS  Google Scholar 

  9. Gallup DG, Harper RH, Stock RJ (1985) Poor prognosis in patients with adenosquamous cell carcinoma of the cervix. Obstet Gynecol 65: 416–422

    PubMed  CAS  Google Scholar 

  10. Gonzales DG, Ketting BW, van Bunningen B, van Duk J (1989) Carcinoma of the uterine cervix stage I b and II a: Results of postoperative irradiation in patients with microscopic infiltration in the parametrium and/or lymph node metastasis. Int J Radiat Oncol Biol Phys 16: 389–395

    Article  Google Scholar 

  11. Gusberg SB, Hermann GG (1968) Radiosensitivity and virulence factors in cervical cancer. Am J Obstet Gynecol 100: 627–639

    PubMed  CAS  Google Scholar 

  12. Hardt N, van Nagell JR, Hanson M, Donaldson E, Yoneda J, Maruyama Y (1982) Radiation-induced tumor regression as a prognostic factor in patients with invasive cervical cancer. Cancer 49: 35–39

    Article  PubMed  CAS  Google Scholar 

  13. Kaltenbach FJ (1977) Histoautoradiographische Untersuchungen benigner und maligner Zellen und Gewebe während therapeutischer Maßnahmen in der Gynäkologie. Fortschr Med 95: 1450–1455

    PubMed  CAS  Google Scholar 

  14. Kapp DS, Fischer D, Guttierrez E, Kohorn EI, Schwartz PE (1983) Pretreatment prognostic factors in carcinoma of the uterine cervix: A multivariable analysis of the effect of age, stage, histology and blood counts on survival. Int J Radiat Oncol Biol Phys 9: 445–455

    Article  PubMed  CAS  Google Scholar 

  15. Kapp DS, Lawrence R (1984) Temperature elevation during brachytherapy for carcinoma of the uterine cervix: Adverse effect on survival and enhancement of distant metastasis. Int J Radiat Oncol Biol Phys 10: 2281–2292

    Article  PubMed  CAS  Google Scholar 

  16. Kim RY, Salter MM, Weppelmann B, Brascho DJ (1988) Analysis of treatment modilities and their failures in stage lb cancer of the cervix. Int J Radiat Oncol Biol Phys 15: 831–835

    Article  PubMed  CAS  Google Scholar 

  17. Kjellgren O (1981) Clinical invasive carcinoma of cervix: place of radiotherapy as primary treatment. In: Coppleson M (ed) Gynecologic oncology. Churchill Livingston, Edinburgh New York, pp 482–503

    Google Scholar 

  18. Kucera H, Enzelsberger H, Eppel W, Weghaupt K (1987) The influence of nicotine abuse and diabetes mellitus on the results of primary irradiation in the treatment of carcinoma of the cervix. Cancer 60: 1–4

    Article  PubMed  CAS  Google Scholar 

  19. Kucera H (1990) Das aktuelle Therapiekonzept der Universitäts-Frauenklinik Wien bei der Bestrahlung des Zervixkarzinoms. In: Teufel G (Hrsg) Therapie des Zervixkarzinoms. Springer, Berlin Heidelberg New York Tokyo, S 221

    Google Scholar 

  20. Ladner H-A (1981) Alte und neue Aspekte zur kombinierten Therapie bei gynäkologischen Tumoren. In: Wannenmacher M, Schreiber AW, Gauwerky F, Ladner H-A, Knüfermann H, Slanina J (Hrsg): Kombinierte chirurgische und radiologische Therapie maligner Tumoren. Urban & Schwarzenberg, München

    Google Scholar 

  21. Ladner H-A (1985) Vitamin B6, cancer and irradiation. Studies over a period of 25 years. In: Ladner H-A, Reiners C, Börner W, Schütz J (Hrsg) 25 Jahre medizinischer Strahlenschutz. Thieme, Stuttgart New York, pp 63–69

    Google Scholar 

  22. Lagasse LD, Creasman WT, Shingleton HM, Fort JH, Blessing JA (1980) Results and complications of operative staging in cervical cancer: Experience of the gynecologic oncology group. Gynecol Oncol 9: 90–98

    Article  PubMed  CAS  Google Scholar 

  23. Lovecchio JL, Averette HE, Donato D, Bell J (1989) 5-year survival of patients with periaortic nodal metastases in clinical stage lb and Ha cervical carcinoma. Gynecol Oncol 34: 43–45

    Google Scholar 

  24. Montana GS, Fowler WC (1989) Carcinoma of the cervix: Analysis of bladder and rectal radiation dose and complications. Int J Radiat Oncol Biol Phys 16: 95–100

    Article  PubMed  CAS  Google Scholar 

  25. Noguchi H, Shiozawa K, Tsukamoto T, Tsukahara Y, Iwai S, Fukuta T (1983) The postoperative classification for uterine cervical cancer and its clinical evaluation. Gynecol Oncol 16: 219–231

    Article  PubMed  CAS  Google Scholar 

  26. Noguchi H, Schiazawa I, Kitahara T, Yamazaki T, Fukuta T (1988) Uterine body invasion of carcinoma of the uterine cervix as seen from surgical specimens. Gynecol Oncol 30: 173–182

    Article  PubMed  CAS  Google Scholar 

  27. Orton C, Wolf-Rosenbaum S (1986) Dose dependence of complication rate in cervix cancer radiotherapy. Int J Radiat Oncol Biol Phys 12: 37–44

    Article  PubMed  CAS  Google Scholar 

  28. Peters LJ, Brock W, Johnson T (1985) Predicting radiocurability. Cancer 55: 2118–2122

    Article  PubMed  CAS  Google Scholar 

  29. Pettersson F (1990) Behandlungsergebnisse des Zervixkarzinoms. Erkenntnisse aus dem FIGO-Jahresbericht. In: Teufel G (Hrsg) Therapie des Zervixkarzinoms. Springer, Berlin Heidelberg New York Tokyo, S 211

    Google Scholar 

  30. Podczaski ES, Palombo D, Manetta A, Andrews C, Larson J, DeGeest K, Mortel R (1989) Assessment of pretreatment laparotomy in patients with cervical carcinoma prior to radiotherapy. Gynecol Oncol 33: 71–75

    Article  PubMed  CAS  Google Scholar 

  31. Randall ME, Constable WC, Hahn SS, Kim JA, Mills SE (1988) Results of the radiotherapeutic management of carcinoma of the cervix with emphasis on the influence of histologic classification. Cancer 62: 48–53

    Article  PubMed  CAS  Google Scholar 

  32. Rutledge FN (1969) Combination irradiation and surgical therapy for carcinoma of the cervix. In: Cancer of the uterus and ovary. Year book, Chicago, pp 216–229

    Google Scholar 

  33. Sablinska B (1979) Carcinoma of the uterine cervix in women over 70 years of age. Gynecol Oncol 7: 128–135

    Article  PubMed  CAS  Google Scholar 

  34. Scherer E (1986) Warum Suche nach Individualisierung bei der radiologischen Tumortherapie? Strahlenther Onkol 162: 621–623

    PubMed  CAS  Google Scholar 

  35. Stanhope CR, Smith JP, Wharton JT, Rutledge FN, Fletcher GH, Gallager S (1980) Carcinoma of the cervix: The effect of age on survival. Gynecol Oncol 10: 188–193

    Article  PubMed  CAS  Google Scholar 

  36. Stuart GCE, Robertson DI, Fedorkow DM, Duggan MA, Nation JG (1988) Recurrent and persistent squamous cell cervical carcinoma in women under age 35. Gynecol Oncol 30: 163–172

    Article  PubMed  CAS  Google Scholar 

  37. Teufel G, Nestle U, Senst A, Kleine W, Pfleiderer A (1990) Ist die Radikaloperation im Stadium II b zu rechtfertigen? In: Teufel G (Hrsg) Therapie des Zervixkarzinoms. Springer, Berlin Heidelberg New York Tokyo, S 153

    Google Scholar 

  38. Thomson JM, Spratt jr JS (1978) Treatment policies affecting survival in patients with carcinoma of the cervix. Radiology 127: 771–774

    PubMed  CAS  Google Scholar 

  39. Vesterinen E, Forss U, Nieminen U (1989) Increase of cervical adenocarcinoma: A report of 520 cases of cervical carcinoma including 112 tumors with glandular elements. Gynecol Oncol 33: 49–53

    Article  PubMed  CAS  Google Scholar 

  40. Vigario G, Kurohara SS, Geroge III JW (1973) Association of hemoglobin levels before and during radiotherapy with prognosis in uterine cervix cancer. Radiology 106: 649–652

    PubMed  CAS  Google Scholar 

  41. Wimhöfer H (1968) Die hormonale und zytostatische Zusatztherapie beim Kollumkarzinom. Geburtshilfe Frauenheilkd 28: 609–616

    PubMed  Google Scholar 

  42. Ylinen K, Nieminen U, Fross M, Widholm O, Karjalainen O (1985) Changing pattern of cervical carcinoma: A report of 709 cases of invasive carcinoma treated in 1970–1974. Gynecol Oncol 20: 386

    Article  Google Scholar 

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© 1990 Springer-Verlag Berlin Heidelberg

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Ladner, HA. (1990). Prognosefaktoren für die Strahlentherapie. In: Teufel, G., Pfleiderer, A., Ladner, HA. (eds) Therapie des Zervixkarzinoms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75058-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-75058-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75059-5

  • Online ISBN: 978-3-642-75058-8

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