Hormonal and Nutritional Factors Contributing to Tumour Cachexia
The majority of cancer patients lose weight (Nixon et al. 1980) and a proportion become emaciated to the point that they appear to die of starvation. This syndrome is known as cancer cachexia, the term cachexia being derived from the Greek words kaxos and hexis, meaning poor condition. The patient with cachexia is clinically characterised by the presence of anorexia, early satiety, severe weight loss, asthenia, anaemia and oedema (Caiman 1982). The importance of cachexia has been long recognised. As far back as 1932 Warren, in a post mortem study of 500 cancer patients, concluded that 22% of deaths were directly attributable to cachexia and this was the single most common cause of death in cancer patients. More recent studies (Inagaki et al. 1974) have suggested that this figure is closer to 10%, however, more than 50% of cancer deaths are attributable to sepsis, and there remains the complex relationship between nutritional depletion and a propensity to infection.
KeywordsObesity Albumin Tyrosine Adenocarcinoma Lipase
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