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Hormonal and Nutritional Factors Contributory to Obesity

  • Conference paper
Hormones and Nutrition in Obesity and Cachexia

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Abstract

In one of the plenary lectures at the Second European Congress on Obesity in Oxford, April 1989, Professor Jeanrenaud gave a masterly review of the similarities between the genetically obese (fa-fa) rat and the rat rendered obese by lesions in the ventromedial hypothalamic nuclei. He was able to link the decreased sympathetic activity, and increased parasympathetic activity, to the increased insulinaemia, decreased thermogenesis, and increase in body fat. I will not venture into discussion of these fascinating animal models of obesity for two reasons: first, I have no first-hand experience of this field of research, and second, because Dr. Rothwell, who will present the next paper, is expert in this field. I will therefore confine my remarks to the hormonal and nutritional factors which contribute to obesity in humans.

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References

  • Avons P, James WPT (1986) Energy expenditure of young men from obese and non-obese families. Hum Nutr Clin Nutr 40C:259–270

    Google Scholar 

  • Blair D, Buskirk ER (1987) Habitual daily energy expenditure and activity levels of lean and adult-onset and child-onset obese women. Am J Clin Nutr 45:540–550

    PubMed  CAS  Google Scholar 

  • Blaza S, Garrow JS (1983) Thermogenic response to temperature, exercise and food stimuli in lean and obese women, studied by 24 h direct calorimetry. Br J Nutr 49:171–180

    PubMed  CAS  Google Scholar 

  • Braitman LE, Adlin EV, Stanton JL (1985) Obesity and caloric intake: the national health and nutrition examination survey of 1971–1975 (HANES I). J Chronic Dis 38:727–732

    Article  PubMed  CAS  Google Scholar 

  • Caballero B, Finer N, Wurtmen RJ (1988) Plasma aminoacids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements. Metabolism 37:672–676

    Article  PubMed  CAS  Google Scholar 

  • De Luise M, Blackburn GL, Flier JS (1980) Reduced activity of red-cell sodium-potassium pump in human obesity. N Engl J Med 303:1153–1158

    Article  Google Scholar 

  • Dore C, Hesp R, Wilkins D, Garrow JS (1982) Prediction of energy requirements of obese patients after massive weight loss. Hum Nutr Clin Nutr 36C:41–48

    PubMed  CAS  Google Scholar 

  • Finer N, Price P, Grossman A, Besser GM (1987) The effect of enkephalin analogue on pituitary hormone release in human obesity. Horm Metab Res 19:68–70

    Article  PubMed  CAS  Google Scholar 

  • Garby L, Garrow JS, Jorgensen B, Lammert O, Madsen K, Sorensen P, Webster J (1988) Relation between energy expenditure and body composition in man: specific energy expenditure in vivo of fat and fat-free tissue. Eur J Clin Nutr 42:301–305

    PubMed  CAS  Google Scholar 

  • Garrow JS (1988) Obesity and related diseases. Churchill, London, pp 329

    Google Scholar 

  • Garrow JS, Webster J (1985) Are pre-obese people energy-thrifty? Lancet i:670–671

    Article  Google Scholar 

  • Griffiths M, Payne P (1976) Energy expenditure in small children of obese and non-obese parents. Nature 260:698–700

    Article  PubMed  CAS  Google Scholar 

  • Jung R, Campbell RG, James WPT, Callingham BA (1982) Altered hypothalamic sympathetic responses to hypoglycaemia in familial obesity. Lancet i:1043–1046

    Article  Google Scholar 

  • Kopelman PG, White N, Pilkington TRE, Jeffcoate SL (1979) Impaired hypothalamic control of prolactin secretion in massive obesity. Lancet i:747–750

    Article  Google Scholar 

  • Kush RD, Young JB, Katzeff HL, Danforth E, Garrow JS, Scheidegger K, Ravussin E, Howard BV, Sims EAH, Horton ES, Landsberg L (1986) Effect of diet on energy expenditure and plasma norepinephrine in lean and obese Pima Indians. Metabolism 12:1110–1120

    Article  Google Scholar 

  • Landsberg L (1986) Diet, obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. Q J Med 236:1081–1090

    Google Scholar 

  • Morley JE, Levine AS (1982) The role of endogenous opiates as regulators of appetite. Am J Clin Nutr 35:757–761

    PubMed  CAS  Google Scholar 

  • Nair KS, Halliday D, Ford GC, Heels S, Garrow JS (1987) Failure of carbohydrate to spare leucine oxidation in obese subjects. Int. J Obes 11:537–544

    PubMed  CAS  Google Scholar 

  • Neel JV (1962) Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet 14:353–362

    PubMed  CAS  Google Scholar 

  • Ng LL, Hockaday TDR (1986) The leucocyte sodium pump in healthy and obese subjects: the association with insulin and its activity. Clin Endocrinol 25:383–392

    Article  CAS  Google Scholar 

  • Prentice AM, Black AE, Coward WA, Davies HL, Goldberg GR, Murgatroyd PR, Ashford J, Sawyer M, Whitehead RG (1986) High levels of energy expenditure in obese women. Br Med J 292:983–987

    Article  CAS  Google Scholar 

  • Ravussin E, Burnand B, Schutz Y, Jequier E (1982) Twenty-four hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects. Am J Clin Nutr 35:566–573

    PubMed  CAS  Google Scholar 

  • Ravussin E, Lillioja S, Knowler WC et al (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med 318:467–72

    Article  PubMed  CAS  Google Scholar 

  • Roberts SB, Savage J, Coward WA, Chew B, Lucas A (1988) Energy expenditure and intake in infants born to lean and overweight mothers. N Engl J Med 318:461–466

    Article  PubMed  CAS  Google Scholar 

  • Schutz Y, Jequier E (1986) Energy expenditure. Lancet i:101–102

    Article  Google Scholar 

  • Sims EAH, Goldman RF, Gluck CM, Horton ES, Kelleher PC, Rowe DW (1968) Experimental obesity in man. Trans Assoc Am Physicians 81:153–170

    PubMed  CAS  Google Scholar 

  • Sims EAH, Danforth E Jr, Horton ES, Bray GA, Glennon JA, Salans LB (1973) Endocrine and metabolic effects of experimental obesity in man. Recent Prog Horm Res 29:457–496

    PubMed  CAS  Google Scholar 

  • Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ, Hales CN (1989) Insulin deficiency in non-insulin-dependent diabetes. Lancet i:293–295

    Article  Google Scholar 

  • Webster JD, Garrow JS (1989) Weight loss in 108 obese women on a diet supplying 800 kcal/d for 21 days. Am J Clin Nutr 50:41–45

    PubMed  CAS  Google Scholar 

  • Wooley SC, Wooley OW, Dunham RB (1972) Can calories be perceived, and do they affect hungerin obese and non-obese humans? J Comp Physiol Psychol 80:250–258

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. S. Garrow
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Editor information

Editors and Affiliations

  1. Department Innere Medizin und Dermatologie, Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61, Germany

    Manfred J. Müller

  2. Clinical Research Center, Medical Center Hospital of Vermont, The University of Vermont, 05041, Burlington, VT, USA

    Elliot Danforth Jr.

  3. Division d’Endocrinologie, Hôpital Cantonal Universitaire, 24 rue Micheli-du-Crest, CH-1211, Genève 4, Switzerland

    Alfred G. Burger

  4. B. Braun Melsungen AG, Postfach 120, D-3508, Melsungen, Germany

    Uwe Siedentopp

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© 1990 Springer-Verlag Berlin Heidelberg

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Garrow, J.S. (1990). Hormonal and Nutritional Factors Contributory to Obesity. In: Müller, M.J., Danforth, E., Burger, A.G., Siedentopp, U. (eds) Hormones and Nutrition in Obesity and Cachexia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75037-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-75037-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51637-8

  • Online ISBN: 978-3-642-75037-3

  • eBook Packages: Springer Book Archive

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