The Role of Ion Channels in the Mechanism of Pancreatic Bicarbonate Secretion
The current model for pancreatic duct cell bicarbonate secretion is shown in Fig. 1 a. It is based on data derived from secretory studies on intact glands (see Case and Argent 1989), together with recent electrophysiological and intracellular pH measurements made on small pancreatic ducts (Gray et al. 1988b; Novak and Greger 1988a, 1988b; Stuenkel etal. 1988). The functions of this secretion are to flush digestive enzymes (secreted by acinar cells) along the ductal tree and into the duodenum and to provide an alkaline environment for the action of these enzymes on food in the gut.
KeywordsPermeability Cage Barium Bicarbonate Luminal
Unable to display preview. Download preview PDF.
- Argent BE, Arkle S, Gray MA, Greenwell JR (1987a) Two types of calcium-sensitive cation channels in isolated rat pancreatic duct cells. J Physiol (Lond) 386: 82PGoogle Scholar
- Argent BE, Gray MA, Greenwell JR (1987b) Characteristics of a large conductance anion channel in membrane patches excised from rat pancreatic duct cells in vitro. J Physiol (Lond) 394: 146PGoogle Scholar
- Argent BE, Coleman L, Gray MA, Greenwell JR, Harris A (1988) Anion-selective channel on the apical plasma membrane of human pancreatic duct cells in vitro. J Physiol 403:49PGoogle Scholar
- Case RM, Argent BE (1989) Pancreatic secretion of electrolytes and water. In: Schultz SG (ed) Handbook of Physiology, Section 6, Vol. III, American Physiological Society, Bethesda, pp 383–417Google Scholar
- Gray MA, Coleman L, Harris A, Greenwell JR, Argent BE (1988 a) Chloride channels on human pancreatic duct cells. In: Wong PYD, Young JA (eds) Exocrine secretion. Hong Kong University Press, Hong Kong, pp 73–75Google Scholar
- Gray MA, Greenwell JR, Argent BE (1988c) Ion channels in pancreatic duct cells: characterization and role in bicarbonate secretion. In: Mastella G, Quinton PM (eds) Cellular and molecular basis of cystic fibrosis. San Francisco Press, San Francisco, pp 205–216Google Scholar
- Hoffman EK, Simonsen LO, Sjoholm C (1979) Membrane potential, chloride exchange, and chloride conductance in Ehrlich mouse ascites tumour cells. J Physiol (Lond) 296: 61–84Google Scholar
- Marty A, Tan YP, Trautmann A (1984) Three types of calcium-dependent channel in rat lacrimal glands. J Physiol (Lond) 357: 293–325Google Scholar