Non-Adrenergic, Non-Cholinergic Control of Salivary Gland Function

  • D. A. Titchen
  • A. M. Reid


It has been recognised for some time that the parasympathetic and sympathetic divisions of the autonomic nervous system may contribute to the regulation of salivary gland function (Babkin 1950; Burgen and Emmelin 1961; Young and Van Lennep 1979; Garrett 1982). Muscarinic cholinergic agonists and antagonists have been used to assess the role of the parasympathetic innervation. Effects of the muscarinic cholinergic innervation include vasodilation and profuse secretion of fluid of relatively low protein concentration. Similarly, the role of the sympathetic innervation has been judged from effects mediated by either α or β adrenoceptors and their block by the appropriate antagonists. Stimulation of α adrenoceptors may produce vasoconstriction, contraction of the myoepithelial cells and in some species, secretion. Stimulation of β adrenoceptors may result in vasodilation and has been shown in a number of species to lead to production of low volumes of fluid with high protein (or enzyme) concentration.


Salivary Gland Parotid Gland Vasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Secretory Response 
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© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  • D. A. Titchen
  • A. M. Reid

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