Genes Coding for G Proteins in Mammalian and Yeast Cells

  • Y. Kaziro
Conference paper
Part of the 40. Colloquium der Gesellschaft für Biologische Chemie 6.– 8. April 1989 in Mosbach/Baden book series (MOSBACH, volume 40)


GTP-binding proteins are classified largely into two groups, i.e., heterotrimeric GTP-binding proteins which are referred to as G proteins, and low-molecular-weight monomeric GTP-binding proteins (LMG) including ras, rap, rho, and rab proteins. The basic mechanism of the reaction catalyzed by these proteins appears to be analogous to that proposed for translational elongation factors (Kaziro 1978). The GTP-bound form is an active conformation which activates the transmission of signals, and the hydrolysis of bound GTP to GDP is required to shift the conformation to an inactive form, i.e., to shut off the signal transduction.


Adenylate Cyclase Pertussis Toxin COOH Terminus Region Receptor Contact Site Yeast Adenylate Cyclase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Y. Kaziro
    • 1
  1. 1.Institute of Medical ScienceUniversity of TokyoMinato-ku, Tokyo 108Japan

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