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Genes Coding for G Proteins in Mammalian and Yeast Cells

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Molecular Mechanisms of Hormone Action

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Abstract

GTP-binding proteins are classified largely into two groups, i.e., heterotrimeric GTP-binding proteins which are referred to as G proteins, and low-molecular-weight monomeric GTP-binding proteins (LMG) including ras, rap, rho, and rab proteins. The basic mechanism of the reaction catalyzed by these proteins appears to be analogous to that proposed for translational elongation factors (Kaziro 1978). The GTP-bound form is an active conformation which activates the transmission of signals, and the hydrolysis of bound GTP to GDP is required to shift the conformation to an inactive form, i.e., to shut off the signal transduction.

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Author information

Authors and Affiliations

  1. Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108, Japan

    Y. Kaziro

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  1. Y. Kaziro
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Editors and Affiliations

  1. Institut für Biologische Chemie, Universität Heidelberg, Im Neuenheimer Feld 510, 6900, Heidelberg, Germany

    Ulrich Gehring

  2. Institut für Physiologische Chemie, Universität Würzburg, Koellikerstr. 2, 8700, Würzburg, Germany

    Ernst J. M. Helmreich

  3. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 1000, Berlin 33, Germany

    Günter Schultz

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© 1989 Springer-Verlag Berlin Heidelberg

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Kaziro, Y. (1989). Genes Coding for G Proteins in Mammalian and Yeast Cells. In: Gehring, U., Helmreich, E.J.M., Schultz, G. (eds) Molecular Mechanisms of Hormone Action. 40. Colloquium der Gesellschaft für Biologische Chemie 6.– 8. April 1989 in Mosbach/Baden, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75022-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-75022-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75024-3

  • Online ISBN: 978-3-642-75022-9

  • eBook Packages: Springer Book Archive

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