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The Structure of the Skeletal and Nonskeletal Muscle Calcium Channel

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Molecular Mechanisms of Hormone Action

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Abstract

A number of fundamental biological processes such as mobility, secretion, and neurotransmission are regulated by a change in the cytosolic calcium concentration. The cytosolic calcium concentration is raised from around 0.1 to 1 µM either by a release from cellular stores or by an influx from the extracellular space through voltage-dependent calcium channels. These channels are located in the plasma and transverse tubular membranes of many cells and are classified into at least three types (Nowycky et al. 1985), the T- (tiny or transient), N- (neither T- nor L-, or neuronal), and L- (large or long-lasting) channels. The L-type channels are the target of different organic drugs, the calcium channel blockers, which are used therapeutically in a variety of cardiovascular diseases. L- and N-type channels are not only regulated by the membrane potential or drugs but also by hormones through phosphorylation and/or G proteins. The electrophysiological properties of the L-type channel have been studied in great detail in cardiac, neuronal, and smooth muscle cells. In contrast, its biochemical and molecular structure has been elucidated up to now only in skeletal muscle.

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Author information

Authors and Affiliations

  1. Institut für Physiologische Chemie, Medizinische Fakultät, Universität des Saarlandes, D-6650, Hom-burg-Saar, Fed. Rep. of Germany

    F. Hofmann, P. Ruth, T. Schneider, J. Felbel, S. Regulla, M. Biel, W. Nastainczyk & V. Flockerzi

Authors
  1. F. Hofmann
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  2. P. Ruth
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  3. T. Schneider
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  4. J. Felbel
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  5. S. Regulla
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  6. M. Biel
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  7. W. Nastainczyk
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  8. V. Flockerzi
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Editor information

Editors and Affiliations

  1. Institut für Biologische Chemie, Universität Heidelberg, Im Neuenheimer Feld 510, 6900, Heidelberg, Germany

    Ulrich Gehring

  2. Institut für Physiologische Chemie, Universität Würzburg, Koellikerstr. 2, 8700, Würzburg, Germany

    Ernst J. M. Helmreich

  3. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, 1000, Berlin 33, Germany

    Günter Schultz

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© 1989 Springer-Verlag Berlin Heidelberg

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Hofmann, F. et al. (1989). The Structure of the Skeletal and Nonskeletal Muscle Calcium Channel. In: Gehring, U., Helmreich, E.J.M., Schultz, G. (eds) Molecular Mechanisms of Hormone Action. 40. Colloquium der Gesellschaft für Biologische Chemie 6.– 8. April 1989 in Mosbach/Baden, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75022-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-75022-9_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75024-3

  • Online ISBN: 978-3-642-75022-9

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