Changes in Structure and Metabolism of Proteoglycans in Aging
Besides the various collagen types I–XII and the elastins, the so-called ground substance, which is composed of glycosaminoglycans and proteoclycans, is produced by specific cells in connective tissues. They are developed from a primitive mesenchymal cell. Specific cells—fibroblasts, chondrocytes, etc.—produce specific tissue types which have a characteristic composition of macromolecules, and also glycosaminoglycans and proteoglycans, which determine the biomechanical properties of the tissue.
KeywordsArthritis Superoxide Serine Osteoarthritis Methionine
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