Gerontology pp 195-202 | Cite as

Changes in Structure and Metabolism of Proteoglycans in Aging

  • H. Greiling
  • R. N. Schöngen
  • K. Kleesiek
  • H. W. Stuhlsatz
Conference paper


Besides the various collagen types I–XII and the elastins, the so-called ground substance, which is composed of glycosaminoglycans and proteoclycans, is produced by specific cells in connective tissues. They are developed from a primitive mesenchymal cell. Specific cells—fibroblasts, chondrocytes, etc.—produce specific tissue types which have a characteristic composition of macromolecules, and also glycosaminoglycans and proteoglycans, which determine the biomechanical properties of the tissue.


Articular Cartilage Chondroitin Sulfate Keratan Sulfate Costal Cartilage Human Cartilage 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Greiling
  • R. N. Schöngen
  • K. Kleesiek
  • H. W. Stuhlsatz
    • 1
  1. 1.Institute of Clinical Chemistry and Pathobiochemistry, Medical FacultyAachen University of TechnologyAachenGermany

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