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Changes in Structure and Metabolism of Proteoglycans in Aging

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Gerontology
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Abstract

Besides the various collagen types I–XII and the elastins, the so-called ground substance, which is composed of glycosaminoglycans and proteoclycans, is produced by specific cells in connective tissues. They are developed from a primitive mesenchymal cell. Specific cells—fibroblasts, chondrocytes, etc.—produce specific tissue types which have a characteristic composition of macromolecules, and also glycosaminoglycans and proteoglycans, which determine the biomechanical properties of the tissue.

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References

  • Cutler RG (1984) Evolutionary biology of aging and longevity in mammalian species. In: Johnson JE (ed) Aging and Cell Function. Plenum Press, New York London, pp 1–147

    Google Scholar 

  • Greiling H, Baumann G (1973) Age-dependent changes of nonsulfated disaccharide groups in the proteoglycans of knee joint cartilage. In: Vogel HG (ed) Connective tissue and ageing. Excerpta Medica, Amsterdam, pp 160–162

    Google Scholar 

  • Greiling H, Kleesiek K, Reinards R (1986) Interaction of synovial cells and synovial fluid with cartilage. In: Kuettner K, Schleyerbach R, Hascall VC (eds) Articular cartilage biochemistry. Raven Press, New York, pp 195–210

    Google Scholar 

  • Heinegard D, Paulsson M (1984) Structure and metabolism of proteoglycans. In: Piez KA, Reddi A H (eds) Exracellular matrix biochemistry. Elsevier, New York Amsterdam Oxford, pp 277–328

    Google Scholar 

  • Honda A, Abe M, Nurata S, Mori Y (1979) The effect of ageing on the synthesis of hexosamine-containing substances from rat costal cartilage. J Biochem 85: 519–528

    PubMed  CAS  Google Scholar 

  • Inerot SI, Heinegard D, Audell L, Olsson S E (1978) Articular cartilage proteoglycans in aging and osteoarthritis. Biochem J 169: 143–156

    PubMed  CAS  Google Scholar 

  • Kaplan D, Meyer K (1959) Ageing of human cartilage. Nature 183: 1267–1268

    Article  PubMed  CAS  Google Scholar 

  • Kleesiek K, Reinards R, Brackertz D, Neumann S, Lang H, Greiling H (1986) Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases. Rheumatol Int 6: 161–169

    Article  PubMed  CAS  Google Scholar 

  • Mathews MB, Glagov S (1966) Acid mucopolysaccaride patterns in ageing human cartilage. J Clin Invest 45: 1103–1111

    Article  PubMed  CAS  Google Scholar 

  • Oberley LW, Oberley TD (1986) Free radicals, cancer, and aging. In: Johnson JE, Walford R, Harman D, Miquel J (eds) Free radicals, aging, and degenerative diseases. Liss, New York, pp 325–371

    Google Scholar 

  • Patton SE, Rosen GM, Rackman E (1980) Superoxide production by purified hamster hepatic nuclei. Mol Pharmacol 18: 588–593

    PubMed  CAS  Google Scholar 

  • Poole AR (1986) Changes in the collagen and proteoglycan of articular cartilage in arthritis. Rheumatology 10: 316–371

    CAS  Google Scholar 

  • Roughley PJ, White RJ (1980) Age-related changes in the structure of the proteoglycan subunits from human articular cartilage. J Biol Chem 255: 217–224

    PubMed  CAS  Google Scholar 

  • Roughley PJ, Mort JS (1986) Ageing and the aggregating proteoglycans of human articular cartilage. Clin Sci 71: 337–344

    PubMed  CAS  Google Scholar 

  • Schiller S (1976) The effect of hormones on synthesis of the region linking chondroitin sulfate to protein. Biochim Biophys Acta 451: 457–464

    Article  PubMed  CAS  Google Scholar 

  • Schwartz NB (1977) Regulation of chondroitin sulfate synthesis. J Biol Chem 252: 6316–6321

    PubMed  CAS  Google Scholar 

  • Stuhlsatz HW, Löffler H, Mohanaradhakrishnan V, Cosma S, Greiling H (1982) Topographic and age-dependent distribution of the glycosaminoglycans in human aorta. J Clin Chem Clin Biochem 20: 713–721

    PubMed  CAS  Google Scholar 

  • Vlassara H, Brownlee M, Cerami A (1986) Nonenzymatic glycosylation: Role in the pathogenesis of diabetic complications. Clin Chem 32: B 37–B 41

    Google Scholar 

  • Wilke TJ (1983) Influence of age and sex on the concentration of free thyroxin in serum and on the free thyroxin: total thyroxin ratio. Clin Chem 29: 1428–1430

    PubMed  CAS  Google Scholar 

  • Wolf B, Gressner AM, Nevo Z, Greiling H (1982) Age-related decrease in the activity of UDP- xylose: core protein xylosyltransferase in rat costal cartilage. Mechanisms of Ageing and Development 19: 181–190

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Greiling, H., Schöngen, R.N., Kleesiek, K., Stuhlsatz, H.W. (1989). Changes in Structure and Metabolism of Proteoglycans in Aging. In: Platt, D. (eds) Gerontology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74996-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-74996-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74998-8

  • Online ISBN: 978-3-642-74996-4

  • eBook Packages: Springer Book Archive

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