Tissue Accessibility of Gd-DTPA in Meningiomas and Neuromas

  • T. Watabe
  • T. Iwata
Conference paper


The relaxation rate of water in the presence of Gd-DTPA (gadolinium-diethylenetriamine pentaacetic acid), a contrast agent in magnetic resonance (MR) imaging, is determined by both the intrinsic relaxation rate of water and the relaxivity or relaxation rate contribution (RRC) of Gd-DTPA, as shown by the following equation (Gadian et al. 1985):
$$ 1/\text{T}_{\text{post}} = \text{RRC + 1/T}_{\text{pre}} , $$
where 1/Tpost and 1/Tpre are either T1 or T2 relaxation of water with and without Gd-DTPA. Although this RRC includes complex physical factors, in living tissue it indicates the degree of tissue concentration of Gd-DTPA or its accessibility to tissue water.


Cerebellopontine Angle Acoustic Neuroma Choroid Plexus Papilloma Magnetic Resonance Contrast Agent Tissue Accessibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berry I, Brant-Zawadzki M, Osaki L, Brasch R, Murovic J, Newton TH (1986) Gd-DTPA in clinical MR of the brain. II. Extraaxial lesions and normal structures. AJNR 7:789–793Google Scholar
  2. Carter LP, Beggs J, Waggener JD (1972) Ultrastructure of three choroid plexus papillomas. Cancer 30:1130–1136PubMedCrossRefGoogle Scholar
  3. Gadian DG, Payne JA, Bryant DJ, Young IR, Carr DH, Bydder GM (1985) Gadolinium-DTPA as a contrast agent in MR imaging - theoretical projections and practical observations. J Comput Assist Tomogr 9:242–251PubMedCrossRefGoogle Scholar
  4. Ham AW (1974) Connective tissue: how fluid passes in and out through capillary walls. In: Ham AW (ed) Histology, 7th edn. Lippincott, Philadelphia, pp 213–215Google Scholar
  5. Hirano A, Dembitzer HM, Zimmerman HM (1972) Fenestrated blood vessels in neurilemoma. Lab Invest 27:305–309PubMedGoogle Scholar
  6. Kasantikul V, Glick AD, Netsky MG (1979) Light and electron microscopic observations of blood vessels in neurilemoma. Arch Pathol Lab Med 103:683–687PubMedGoogle Scholar
  7. Long DM (1973) Vascular ultrastructure in human meningiomas and schwannomas. J Neurosurg 38:409–419PubMedCrossRefGoogle Scholar
  8. Mikhael MA, Ciric IS, Wolff AP (1985) Differentiation of cerebellopontine angle neuromas and meningiomas with MR imaging. J Comput Assist Tomogr 9:852–856PubMedCrossRefGoogle Scholar
  9. Press GA, Hesselink JR (1988) MR imaging of cerebellopontine angle and internal auditory canal lesions at 1.5 T. AJNR 9:241–251Google Scholar
  10. Ramsey HJ (1966) Fine structure of hemangiopericytoma and hemangioendothelioma. Cancer 19:2005–2018PubMedCrossRefGoogle Scholar
  11. Riederer SJ, Bobman SA, Lee JN, Farzaneh F, Wang HZ (1986) Improved precision in calculated T1 MR images using multiple spin-echo acquisition. J Comput Assist Tomogr 10:103–110PubMedCrossRefGoogle Scholar
  12. Schelin U (1962) Chromophobe and acidophil adenomas of the human pituitary gland. A light and electron microscopic study. Acta Pathol Microbiol Scand [Suppl] 158:5–80Google Scholar
  13. Schmiedl U, Ogan M, Paajanen H, Marotti M, Crooks LE, Brito AC, Brasch RC (1987) Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies. Radiology 162:205–210PubMedGoogle Scholar
  14. Watabe T, Azuma T (1989) T1 and T2 measurement of meningiomas and neuromas before and after Gd-DTPA. AJNR 10:463–470PubMedGoogle Scholar
  15. Weinmann H-J, Brasch RC, Press W-R, Wesbey GE (1984) Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. AJR 142:619–624PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • T. Watabe
    • 1
  • T. Iwata
  1. 1.Department of RadiologyTokai University School of MedicineBohseidai, Isehara City, Kanagawa Pref. 259-11Japan

Personalised recommendations