Abstract
When a microbial pathogen meets a mammalian organism, different kinds of relationship may evolve. Exotoxin-producing pathogens can harm the host in a dramatic way without becoming too involved themselves. Purulent bacteria colonize extracellular niches from which they can cause acute-type diseases. In both cases, humoral immunity has a profound effect, and normally either type of pathogen is rapidly eliminated once it is taken up by professional phagocytes. So-called intracellular pathogens establish a lifestyle inside host cells, and many of them survive within macrophages at least for some time. Bacteria of this group include Mycobacterium tuberculosis, M. bovis, M. leprae, Salmonella typhi, Legionella pneumophila, and Listeria monocytogenes—the etiologic agents of tuberculosis, leprosy, typhoid fever, Legionnaire’s disease, and listeriosis, respectively. Although macrophages provide a major habitat for these microorganisms, other host cells can be affected as well, with M. leprae-infected Schwann’s cell providing a notable example.
Work from this laboratory received financial support to S.H.E.K. from: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases; the WHO as part of its Program For Vaccine Development; Sonderforschungs-bereich 322; German Leprosy Relief Association; EEC-India Science and Technology Cooperation Program. S.H.E.K. is recipient of the A. Krupp award for young professors; T.K. is supported by the Alexander von Humboldt Foundetion; and M.E.M. is supported by the Conselho Nacional de Deservolvimento Cientifico e Tecnologico, Brazil
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Kaufmann, S.H.E., Schoel, B., Wand-Württenberger, A., Steinhoff, U., Munk, M.E., Koga, T. (1990). T-Cells, Stress Proteins, and Pathogenesis of Mycobacterial Infections. In: Kaufmann, S.H.E. (eds) T-Cell Paradigms in Parasitic and Bacterial Infections. Current Topics in Microbiology and Immunology, vol 155. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74983-4_9
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