T-Cells, Stress Proteins, and Pathogenesis of Mycobacterial Infections

  • S. H. E. Kaufmann
  • B. Schoel
  • A. Wand-Württenberger
  • U. Steinhoff
  • M. E. Munk
  • T. Koga
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 155)


When a microbial pathogen meets a mammalian organism, different kinds of relationship may evolve. Exotoxin-producing pathogens can harm the host in a dramatic way without becoming too involved themselves. Purulent bacteria colonize extracellular niches from which they can cause acute-type diseases. In both cases, humoral immunity has a profound effect, and normally either type of pathogen is rapidly eliminated once it is taken up by professional phagocytes. So-called intracellular pathogens establish a lifestyle inside host cells, and many of them survive within macrophages at least for some time. Bacteria of this group include Mycobacterium tuberculosis, M. bovis, M. leprae, Salmonella typhi, Legionella pneumophila, and Listeria monocytogenes—the etiologic agents of tuberculosis, leprosy, typhoid fever, Legionnaire’s disease, and listeriosis, respectively. Although macrophages provide a major habitat for these microorganisms, other host cells can be affected as well, with M. leprae-infected Schwann’s cell providing a notable example.


Stress Protein Heat Shock Response Mycobacterial Infection Shared Epitope Reactive Oxygen Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. H. E. Kaufmann
    • 1
  • B. Schoel
    • 1
  • A. Wand-Württenberger
    • 1
  • U. Steinhoff
    • 1
  • M. E. Munk
    • 1
  • T. Koga
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of UlmUlmGermany

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