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T-Cell Antigens and Epitopes in Malaria Vaccine Design

  • Conference paper
T-Cell Paradigms in Parasitic and Bacterial Infections

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 155))

Abstract

T cells are central to the development of an immune response, whether it be a humoral or a cell-mediated response. In this sense, all protein antigens can be regarded as potential T-cell antigens. Recent developments in understanding the processes involved in T-cell activation now allow us rigorously to examine the T-cell response to a given organism in terms of antigen specificity, epitope identification, the effects of antigenic variation, the role of different T-cell subsets in immunity to different pathogens, etc. In terms of vaccine development, such a rigorous approach has not been previously used, as empirical measures have often sufficed. However, the development of vaccines for complex organisms, for example, the malaria parasite, may require more insight from a molecular immunological approach. This will certainly be the case if one hopes to develop a “subunit” vaccine consisting of one or a few antigens or parts of them. In this review, the T-cell response to already identified malaria vaccine candidate antigens is examined, the role of cellular immunity to malaria is discussed and the problem of identifying other important antigens with respect to T-cell activation is addressed.

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Authors and Affiliations

  1. The Tropical Health Program, Queensland Institute of Medical Research, Bramston Terrace, Herston, 4006, Queensland, Australia

    M. F. Good

  2. The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    L. H. Miller

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  1. M. F. Good
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  1. Dept. of Medical Microbiology and Immunology, University of Ulm, A.-Einstein-Allee 11, D-7900, Ulm, Germany

    Stefan H. E. Kaufmann

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Good, M.F., Miller, L.H. (1990). T-Cell Antigens and Epitopes in Malaria Vaccine Design. In: Kaufmann, S.H.E. (eds) T-Cell Paradigms in Parasitic and Bacterial Infections. Current Topics in Microbiology and Immunology, vol 155. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74983-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-74983-4_5

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