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T-Cell Paradigms in Parasitic and Bacterial Infections pp 21–31Cite as

Cell-Mediated Immune Response to Schistosomiasis

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 155))

Abstract

Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma, of which three species (S. mansoni, S. hematobium, and S.japonicum) are the principal causes of disease in man. Schistosomiasis is a major health problem in the developing world, with an estimated 200 million persons infected and 600 million living in endemic areas where they are at risk of infection of (BERGQUIST 1987). This helminth parasite is acquired by man or other mammalian hosts through contact with a larval form found in fresh water. Having penetrated the skin, the larvae migrate and mature into adult worms living in the veins of the intestinal or urinary tract. Paired male and female worms produce hundreds to thousands of eggs per day, which are either excreted or become trapped in the body tissues of the host. Schistosomiasis is primarily a chronic disease, the pathology of which is associated with reaction to these trapped eggs. However the estimated mortality rate of approximately 1% (BERGQUIST 1987) translates into hundreds of thousands of lives lost annually.

The ongoing research described here is supported in part by grants from the Edna McConnell Clark Foundation and the World Health Organization

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Author information

Authors and Affiliations

  1. Immunology and Cell Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20892, USA

    S. L. James & A. Sher

Authors
  1. S. L. James
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  2. A. Sher
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Editor information

Editors and Affiliations

  1. Dept. of Medical Microbiology and Immunology, University of Ulm, A.-Einstein-Allee 11, D-7900, Ulm, Germany

    Stefan H. E. Kaufmann

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© 1990 Springer-Verlag Berlin Heidelberg

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James, S.L., Sher, A. (1990). Cell-Mediated Immune Response to Schistosomiasis. In: Kaufmann, S.H.E. (eds) T-Cell Paradigms in Parasitic and Bacterial Infections. Current Topics in Microbiology and Immunology, vol 155. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74983-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-74983-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74985-8

  • Online ISBN: 978-3-642-74983-4

  • eBook Packages: Springer Book Archive

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