T-Cell Antigens and Epitopes in Schistosomiasis
An ideal vaccine must duplicate the stimulus of natural infection and minimize the side effects that can interfere with its efficiency. New approaches to vaccine development using protein subunits or synthetic polypeptides must consider the problem of designing vaccines in such a way as to obtain optimal T-cell activity. Indeed, one characteristic feature of T-lymphocyte recognition is that foreign antigens are recognized by the T-cell receptor as peptidic fragments associated with class I or II major histocompatibility complex (MHC) proteins. Thus, knowledge of the T-cell repertoire in relation to the haplotype expressed is of primary importance in selecting, among the various mechanisms involved in the immune response, those leading to the more efficient protection against the infectious agents.
KeywordsProtective Immunity Schistosoma Mansoni Passive Transfer Adult Worm Antigen Macro Phage
Unable to display preview. Download preview PDF.
- Balloul JM, Boulanger D, Sondermeyer P, Dreyer P, Capron M, Grzych JM, Pierce RJ, Carvallo D, Lecocq JP, Capron A (1987c) Vaccination of baboons with a P28 antigen of S. mansoni expressed in E. coli. In: Molecular paradigms for eradicating helminthic parasites. Liss, New York, pp 77–84.Google Scholar
- Capron M, Leprevost C, Torpier C, Capron A (1989) The second receptor for IgE in eosinophil effector functions. Prog Allergy (in press).Google Scholar
- Damonneville M, Auriault C, Verwaerde C, Delanoye A, Pierce RJ, Capron A (1986) Protection against experimental Schistosoma mansoni schistosomiasis achieved by immunization with schistosomula released products antigens (SRP-A): role of IgE antibodies. Clin Exp Immunol 65: 244–252.PubMedGoogle Scholar
- James SL (1985) Induction of protective immunity against Schistosoma mansoni by non-living vaccine is dependent on the method of antigen presentation. J Immunol 129: 2206–2211.Google Scholar
- James SL, Sher A (1983a) Influence of adjuvant on induction of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. IV. Analysis of the role of IgE antibodies and mast cells. J Immunol 131: 1460–1467.Google Scholar
- James SL, Sher A (1983b) Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. III. Identification of a mouse strain P/N that fails to respond to vaccination. Parasite Immunol 6: 319–329.Google Scholar
- James SL, Skamene E, Meltzer MS (1983b) Macrophages as effector cells of protective immunity in murine schistosomiasis. V. Variation in macrophage schistosomulacidal and tumoricidal activities among mouse strains and correlation with resistance to reinfection. J Immunol 131: 948–953.PubMedGoogle Scholar
- Minard P, Dean DA, Jacobson RJ, Vannier WE, Murrel (1978) Immunization of mice with cobalt-60 irradiated Schistosoma mansoni larvae. Am J Trop Med Hyg 26: 76–86.Google Scholar
- Mosman TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clones: definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348–2357.Google Scholar
- Pearce EJ, James SL, Dalton J, Barrali A, Ramos C, Strand M, Sher A (1986) Immunochemical characterization and purification of Sm-97 a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a non-living antigen. J Immunol 137: 3593–3599.PubMedGoogle Scholar