T-Cell Antigens and Epitopes in Schistosomiasis

  • C. Auriault
  • I. Wolowczuk
  • M. Damonneville
  • F. Velge-Roussel
  • V. Pancré
  • H. Gras-Masse
  • A. Tartar
  • A. Capron
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 155)


An ideal vaccine must duplicate the stimulus of natural infection and minimize the side effects that can interfere with its efficiency. New approaches to vaccine development using protein subunits or synthetic polypeptides must consider the problem of designing vaccines in such a way as to obtain optimal T-cell activity. Indeed, one characteristic feature of T-lymphocyte recognition is that foreign antigens are recognized by the T-cell receptor as peptidic fragments associated with class I or II major histocompatibility complex (MHC) proteins. Thus, knowledge of the T-cell repertoire in relation to the haplotype expressed is of primary importance in selecting, among the various mechanisms involved in the immune response, those leading to the more efficient protection against the infectious agents.


Protective Immunity Schistosoma Mansoni Passive Transfer Adult Worm Antigen Macro Phage 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. Auriault
    • 1
  • I. Wolowczuk
    • 1
  • M. Damonneville
    • 1
  • F. Velge-Roussel
    • 1
  • V. Pancré
    • 1
  • H. Gras-Masse
    • 2
  • A. Tartar
    • 2
  • A. Capron
    • 1
  1. 1.Centre d’ Immunologie et de Biologie ParasitaireUnité Mixte Inserm U167-CNRS 624, Institut PasteurLille CédexFrance
  2. 2.Laboratoire de Chimie des BiomoléculesInstitut PasteurLille CédexFrance

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