T-Cell Antigens and Epitopes in Schistosomiasis

  • C. Auriault
  • I. Wolowczuk
  • M. Damonneville
  • F. Velge-Roussel
  • V. Pancré
  • H. Gras-Masse
  • A. Tartar
  • A. Capron
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 155)

Abstract

An ideal vaccine must duplicate the stimulus of natural infection and minimize the side effects that can interfere with its efficiency. New approaches to vaccine development using protein subunits or synthetic polypeptides must consider the problem of designing vaccines in such a way as to obtain optimal T-cell activity. Indeed, one characteristic feature of T-lymphocyte recognition is that foreign antigens are recognized by the T-cell receptor as peptidic fragments associated with class I or II major histocompatibility complex (MHC) proteins. Thus, knowledge of the T-cell repertoire in relation to the haplotype expressed is of primary importance in selecting, among the various mechanisms involved in the immune response, those leading to the more efficient protection against the infectious agents.

Keywords

Carboxyl Bacillus Polypeptide Interferon Capron 

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References

  1. Auriault C, Damonneville M, Verwaerde C, Pierce RJ, Joseph M, Capron M, Capron A (1984) Rat IgE directed against schistosomula released products is cytotoxic for Schistosoma mansoni schistosomula in vitro. Eur J Immunol 14: 132–138.PubMedCrossRefGoogle Scholar
  2. Auriault C, Damonneville M, Joseph M, Capron M, Verwaerde C, Billaut P, Capron A (1985) Defined antigens secreted by the larve of schistosomes protect against schistosomiasis: induction of cytotoxic antibodies in the rat and the monkey. Eur J Immunol 15: 1168–1172.PubMedCrossRefGoogle Scholar
  3. Auriault C, Balloul JM, Pierce RJ, Damonneville M, Sondermeyer P, Capron A (1987) Helper T cells induced by a purified 28-kilodalton antigen of Schistosoma mansoni protects rat against infection. Infect Immun 55: 1163–1169.PubMedGoogle Scholar
  4. Auriault C, Gras-Masse H, Wolowczuk I, Pierce RJ, Balloul JM, Neyrinck JL, Drobecq H, Tartar A, Capron A (1988) Analysis of T and B cell epitopes of the Schistosoma mansoni P28 antigen in the rat model by using synthetic peptides. J Immunol 141: 1687–1694.PubMedGoogle Scholar
  5. Balloul JM, Grzych JM, Pierce RJ, Capron A (1987a) A purified 28 000 dalton protein from Schistosoma mansoni worms protects rats and mice against experimental S. mansoni. J Immunol 138: 3448–3453.PubMedGoogle Scholar
  6. Balloul JM, Sondermeyer P, Dreyer D, Capron M, Grzych JM, Pierce RJ, Carvallo D, Lecocq JP, Capron A (1987b) Molecular cloning of a protective antigen against schistosomiasis. Nature 326: 149–155.PubMedCrossRefGoogle Scholar
  7. Balloul JM, Boulanger D, Sondermeyer P, Dreyer P, Capron M, Grzych JM, Pierce RJ, Carvallo D, Lecocq JP, Capron A (1987c) Vaccination of baboons with a P28 antigen of S. mansoni expressed in E. coli. In: Molecular paradigms for eradicating helminthic parasites. Liss, New York, pp 77–84.Google Scholar
  8. Bazin H, Capron A, Capron M, Joseph M, Dessaint JP, Pauwels R (1980) Effect of neonatal injection of anti-μ antibodies on immunity to schistosomes. J Immunol 124: 2373–2377.PubMedGoogle Scholar
  9. Bout D, Joseph M, David JR, Capron A (1981) In vitro killing of S. mansoni schistosomula by lymphokine activated mouse macrophage. J Immunol 127: 1–7.PubMedGoogle Scholar
  10. Butterworth AB, Vadas MA, Martz E, Sher A (1979) Cytolytic T lymphocytes recognize alloantigen on schistosomula of Schistosoma mansoni but fail to induce damage. J Immunol 122: 1314–1360.PubMedGoogle Scholar
  11. Capron A, Dessaint JP, Capron M, Bazin H (1975) Specific IgE antibodies in immune adherence of normal macrophages to S. mansoni schistosomules. Nature 253: 474–476.PubMedCrossRefGoogle Scholar
  12. Capron A, Dessaint JP, Capron M, Joseph M, Torpier G (1982) Effector mechanisms of immunity to schistosomes and their regulation. Immunol Rev 61: 41–66.PubMedCrossRefGoogle Scholar
  13. Capron M, Bazin H, Joseph M, Capron A (1981) Evidence for IgE-dependent cytotoxicity by rat eosinophils. J Immunol 126: 1764–1770.PubMedGoogle Scholar
  14. Capron M, Nogueira-Queiroz JA, Papin JP, Capron A (1984) Interaction between eosinophils and antibodies: in vitro protective role against rat schistosomiasis. Cell Immunol 83: 60–72.PubMedCrossRefGoogle Scholar
  15. Capron M, Leprevost C, Torpier C, Capron A (1989) The second receptor for IgE in eosinophil effector functions. Prog Allergy (in press).Google Scholar
  16. Cioli D, Dennert G (1976) The course of Schistosoma mansoni infection in thymectomized rats. J Immunol 117: 59–65.PubMedGoogle Scholar
  17. Cioli D, Knopf PM, Senft AW (1977) Study of Schistosoma mansoni transferred into permissive and non-permissive hosts. Int J Parasitol 7: 293–297.PubMedCrossRefGoogle Scholar
  18. Coffman RL, Carty J (1986) T cell activity that enhance polyclonal IgE production and its inhibition by interferon γ. J Immunol 136: 949–954.PubMedGoogle Scholar
  19. Damonneville M, Auriault C, Verwaerde C, Delanoye A, Pierce RJ, Capron A (1986) Protection against experimental Schistosoma mansoni schistosomiasis achieved by immunization with schistosomula released products antigens (SRP-A): role of IgE antibodies. Clin Exp Immunol 65: 244–252.PubMedGoogle Scholar
  20. Damonneville M, Velge F, Verwaerde C, Pestel J, Auriault C, Capron A (1987) Generation and functional analysis of T cell lines and clones specific for schistosomula released products (SRP-A). Clin Exp Immunol 69: 299–307.PubMedGoogle Scholar
  21. Damonneville M, Wietzerbin J, Pancré V, Joseph M, Delanoye A, Capron A, Auriault C (1988) Recombinant tumor necrosis factor mediate platelet cytotoxicity to Schistosoma mansoni larvae. J Immunol 140: 3962–3965.PubMedGoogle Scholar
  22. Dissous C, Dissous C, Capron A (1981) Isolation and characterization of surface antigens from Schistosoma mansoni schistosomula. Mol Biochem Parasitol 3: 125–131.CrossRefGoogle Scholar
  23. Grzych JM, Capron M, Bazin H, Capron A (1982) In vitro and in vivo effector functions of rat IgG2a monoclonal anti-S. mansoni antibodies. J Immunol 129: 2739–2744.PubMedGoogle Scholar
  24. James SL (1985) Induction of protective immunity against Schistosoma mansoni by non-living vaccine is dependent on the method of antigen presentation. J Immunol 129: 2206–2211.Google Scholar
  25. James SL, Pearce EJ (1988) Influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis. J Immunol 140: 2753–2759.PubMedGoogle Scholar
  26. James SL, Sher A (1983a) Influence of adjuvant on induction of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. IV. Analysis of the role of IgE antibodies and mast cells. J Immunol 131: 1460–1467.Google Scholar
  27. James SL, Sher A (1983b) Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. III. Identification of a mouse strain P/N that fails to respond to vaccination. Parasite Immunol 6: 319–329.Google Scholar
  28. James SL, Lazdin JK, Meltzer MS, Sher A (1982) Macrophages as effector cells of protective immunity in murine schistosomiasis. I. Activation of peritoneal macrophages during natural infection. Cell Immunol 67: 255–266.PubMedCrossRefGoogle Scholar
  29. James SL, Lazdin JK, Hieny S, Natovitz (1983a) Macrophages as effector cells of protective immunity in murine schistosomiasis. VI. T cell-dependent mediated activation of macrophage in response to Schistosoma mansoni antigens. J Immunol 131: 1481–1488.PubMedGoogle Scholar
  30. James SL, Skamene E, Meltzer MS (1983b) Macrophages as effector cells of protective immunity in murine schistosomiasis. V. Variation in macrophage schistosomulacidal and tumoricidal activities among mouse strains and correlation with resistance to reinfection. J Immunol 131: 948–953.PubMedGoogle Scholar
  31. James SL, Dehlois LA, AI-Zamel F, Glaven J, Langhorne J (1986) Defective vaccine-induced resistance to Schistosoma mansoni in P strain mice. III. Specificity of the associated defect in cell-mediated immunity. J Immunol 137: 3959–3967.PubMedGoogle Scholar
  32. Joseph M, Auriault C, Capron A, Vorng H, Viens P (1983) A new function for platelets: IgE-dependent killing of schistosomes. Nature 303: 810–812.PubMedCrossRefGoogle Scholar
  33. Kelly EAB, Colley DG (1988) In vivo effect of monoclonal anti-L3T4 antibody on immune responsiveness of mice infected with Schistosoma mansoni. Reduction of irradiated cercariae-induced resistance. J Immunol 140: 2737–2745.PubMedGoogle Scholar
  34. Lanar D, Pearce ES, James SL, Sher A (1986) Identification of paramyosin as schistosome antigen recognized by intradermally vaccinated mice. Science 234: 593–595.PubMedCrossRefGoogle Scholar
  35. Mangold BL, Dean DA (1986) Passive transfer with serum and IgG antibodies of irradiated cercariae induced resistance against Schistosoma mansoni in mice. J Immunol 136: 2644–2650.PubMedGoogle Scholar
  36. Minard P, Dean DA, Jacobson RJ, Vannier WE, Murrel (1978) Immunization of mice with cobalt-60 irradiated Schistosoma mansoni larvae. Am J Trop Med Hyg 26: 76–86.Google Scholar
  37. Molinas FC, Wietzerbin J, Falcoff E (1987) Human platelets possess receptors for a lymphokine: demonstration of high specific receptors for Hu IFNγ. J Immunol 138: 802–806.PubMedGoogle Scholar
  38. Mosman TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clones: definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348–2357.Google Scholar
  39. Pancré V, Joseph M, Mazingue C, Wietzerbin J, Capron A, Auriault C (1987) Induction of platelet cytotoxic functions by lymphokines: role of interferon γ. J Immunol 138: 4490–4495.PubMedGoogle Scholar
  40. Pancré V, Joseph M, Capron A, Wietzerbin J, Kusnierz JP, Vorng H, Auriault C (1988) Recombinant human interferon γ induces increased IgE receptor expression on human platelets. Eur J Immunol 18: 829–832.PubMedCrossRefGoogle Scholar
  41. Pearce EJ, James SL (1986) Post lung-stage schistosomula of Schistosoma mansoni exhibit transient susceptibility to macrophage-mediated cytotoxicity in vitro that may relate to late phase killing in vivo. Parasite Immunol 8: 513–527.PubMedCrossRefGoogle Scholar
  42. Pearce EJ, James SL, Dalton J, Barrali A, Ramos C, Strand M, Sher A (1986) Immunochemical characterization and purification of Sm-97 a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a non-living antigen. J Immunol 137: 3593–3599.PubMedGoogle Scholar
  43. Pestel J, Dissous C, Dessaint JP, Louis J, Engers H, Capron A (1985) Specific Schistosoma mansoni rat T cell clones. I. Generation and functional analysis in vitro and in vivo. J Immunol 134: 4132–4139.PubMedGoogle Scholar
  44. Phillips SM, Bentley AG, Linette G, Doughty BL, Capron M (1983) The immunologic response of congenitally athymic rats to Schistosoma mansoni infection. J Immunol 131: 1466–1474.PubMedGoogle Scholar
  45. Sher A, Smithers SR, MacKenzie P (1975) Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology 70: 347–354.PubMedCrossRefGoogle Scholar
  46. Sher A, Hieny S, James SL, Asofsky R (1982) Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. J Immunol 128: 1880–1886.PubMedGoogle Scholar
  47. Sher A, Wader A, Joffe M (1983) The enhancement of eosinophil function by lymphocyte supernatants. Clin Exp Immunol 51: 525–532.PubMedGoogle Scholar
  48. Smithers SR, Terry RJ (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55: 695–706.PubMedGoogle Scholar
  49. Smithers SR, Terry RJ (1976) The immunology of schistosomiasis. Adv Parasitol 14: 399–410.PubMedCrossRefGoogle Scholar
  50. Veith M, Pestel J, Loiseau S, Capron M, Capron A (1985) Eosinophil activation by lymphokines and T Cell clone products in the rat. Eur J Immunol 15: 1244–1250.PubMedCrossRefGoogle Scholar
  51. Verwaerde C, Joseph M, Capron M, Pierce RJ, Damonneville M, Velge F, Auriault C, Capron A (1987) Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. J Immunol 138: 4441–4446.PubMedGoogle Scholar
  52. Wolowczuk I, Auriault C, Gras-Masse H, Vendeville C, Balloul JM, Tartar A, Capron A (1989) Protective immunity in mice vaccinated with the Schistosoma mansoni P28-1 antigen. J Immunol 142: 1342–1350.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. Auriault
    • 1
  • I. Wolowczuk
    • 1
  • M. Damonneville
    • 1
  • F. Velge-Roussel
    • 1
  • V. Pancré
    • 1
  • H. Gras-Masse
    • 2
  • A. Tartar
    • 2
  • A. Capron
    • 1
  1. 1.Centre d’ Immunologie et de Biologie ParasitaireUnité Mixte Inserm U167-CNRS 624, Institut PasteurLille CédexFrance
  2. 2.Laboratoire de Chimie des BiomoléculesInstitut PasteurLille CédexFrance

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