Cellular and Molecular Basis of the Protective Immune Response to Cytomegalovirus Infection

  • U. H. Koszinowski
  • M. Del Val
  • M. J. Reddehase
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 154)


Cytomegalovirus (CMV) infection can occur throughout life. Similar to other herpesviruses, after primary infection CMV remains in the host in a latent state. Infection of the immunocompetent host does not cause clinical symptoms, whereas infection of the immunocompromised host can cause severe and even fatal disease. Morbidity and mortality associated with primary CMV infection or with reactivation from latency is common in immunosuppressed transplant recipients and in patients with immunodeficiency caused by HIV infection. CMV pneumonia is considered the immediate cause of death in these patients.


Major Histocompatibility Complex Major Histocompatibility Complex Class Cytomegalovirus Infection Protective Immune Response Salivary Gland Tissue 
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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • U. H. Koszinowski
    • 1
  • M. Del Val
    • 1
  • M. J. Reddehase
    • 1
  1. 1.Department of Virology, Institute for MicrobiologyUniversity of UlmUlmGermany

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