Human Cytomegalovirus Early Gene Expression

  • D. H. Spector
  • K. M. Klucher
  • D. K. Rabert
  • D. A. Wright
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 154)

Abstract

Human cytomegalovirus (HCMV), a member of the herpesvirus group, is species specific and can establish both persistent and latent infections. The virus appears to be able to infect a number of cell types in vivo including epithelial cells, neural cells, endothelial cells, mesenchymal cells, and some subclasses of leukocytes, although viral gene expression may be limited in some of these cells. Within the past 30 years, this virus has been recognized as an important pathogen of man capable of causing disease that affects all age groups worldwide (for review, see Ho 1982; Nankervis and Kumar 1978; Rapp 1983; Spector 1985). In developed countries, it is the major viral cause of birth defects leading to mental retardation and deafness. Transmission of HCMV usually occurs via salivary secretions, sexual contact, or blood, and it remains the most common transfusion-related pathogen. Although primary infection may be asymptomatic or result in a mononucleosis-like syndrome in the immunocompetent individual, severe and sometimes fatal HCMV infections frequently develop in immunocompromised persons, particularly premature infants, organ transplant recipients, and AIDS patients. In AIDS, HCMV is a serious opportunistic infection (Drew et al. 1982; Macher et al. 1983; Marchevsky et al. 1985; Spector et al. 1984; Spector and Spector 1985) and is frequently implicated as a possible cofactor in the development or progression of the disease.

Keywords

Codon Glycine Proline Polypeptide Methionine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • D. H. Spector
    • 1
  • K. M. Klucher
    • 1
  • D. K. Rabert
    • 1
  • D. A. Wright
    • 1
  1. 1.Department of Biology and Center for Molecular GeneticsUniversity of CaliforniaSan Diego, La JollaUSA

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