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The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement

  • Conference paper
The Third Component of Complement

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 153))

Abstract

The third component of complement (C3) may be activated on a cell surface by either the classical or the alternative complement pathways and is covalently bound to the cell surface as C3b. C3b is a cofactor in the activation of the terminal compoments of C5-C9. In addition, it serves as the ligand for the type 1 complement receptor (CR1). C3b loses both of these functions when it undergoes proteolytic cleavage to iC3b and C3f by factor I. The relatively stable iC3b opsonin may then undergo proteolysis to C3c and C3dg in the presence of serum. Both iC3b and C3dg remain surface bound and are recognized by the leukocyte type 3 complement receptor (CR3) and the type 2 complement receptor (CR2), respectively. Of the surface-bound fragments of C3, iC3b is probably the most stable of the cell-associated C3 fragments and is thought to play a major role in the complement-mediated clearance of micro-organisms.

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    H. Rosen

  2. The MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK

    S. K. Alex Law

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  1. H. Rosen
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  2. S. K. Alex Law
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    John D. Lambris Ph. D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Rosen, H., Alex Law, S.K. (1990). The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement. In: Lambris, J.D. (eds) The Third Component of Complement. Current Topics in Microbiology and Immunology, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74977-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-74977-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74979-7

  • Online ISBN: 978-3-642-74977-3

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