Molecular Modelling of C3 and its Ligands
Progress in determining the primary structures of complement components has been very rapid during the 1980s, and, with a few minor gaps, the amino acid sequences of all of the recognised soluble components of the system have been determined from protein or DNA sequencing. The primary structures of many cell-surface components, including complement receptor types 1–4 (CR1, CR2, CR3, CR4), membrane cofactor protein (MCP) and decay-accelerating factor (DAF), all of which interact with fragments of C3, have also been derived from DNA sequences (for review see R. D. CAMPBELL et al. 1988; REID and DAY 1989; DAY 1989).
KeywordsCysteine Fourier Transform Infrared Spectroscopy Serine Proline Carbonyl
Unable to display preview. Download preview PDF.
- Baron M, Willis AC, Bazar K, Campbell ID, Sim RB, Day AJ (1989) NMR studies of the structure of the complement control protein repeat. Complement Inflammation 6: 311 (abstr)Google Scholar
- Bartow T, Klickstein LB, Wong W, Roux K, Fearon DT (1989) Analysis of the tertiary structure of CR1 by electron microscopy. FASEB J 3: A501 (abstr)Google Scholar
- Caporale LH, Woods D, Gagnon J, Christie DL, Bing DH (1984) A computer-generated model of the serine proteinase domain of human complement factor B. Immunobiology 164: 213 (abstr)Google Scholar
- Day AJ (1989) Structure and evolution of the complement system proteins. In: Sim RB (ed) Biochemistry and molecular biology of the complement system. Kluwer, Lancaster (in press)Google Scholar
- Perkins SJ, Nealis AS, Sim RB (1989b) Molecular modelling of human complement component C4 and its fragments by X-ray and neutron solution scattering. Biochemistry (in press)Google Scholar
- Perkins SJ, Smith KF, Nealis AS, Lachmann PJ, Harrison RA, Sim RB (1989c) Domain structures of the complement components C3, C4 and C5 by X-ray and neutron scattering. Complement Inflammation 6: 384 (abstr)Google Scholar
- Smith CA, Pangburn MK, Vogel C-W, Müller-Eberhard HJ (1984a) Structural investigations of properdin and factor H of human complement. Immunobiology 164: 298 (abstr)Google Scholar
- Thiel S, Reid KBM (1989) Structures and functions associated with the group of mammalian lectins containing collagen-like sequences. FEBS Lett (in press)Google Scholar
- Vogel C-W, Smith CA, Müller-Eberhard HJ (1984) Cobra venom factor: structural homology with the third component of complement. J ImmunolGoogle Scholar
- Wuthrich K (1986) NMR of proteins and nucleic acids. Wiley, New YorkGoogle Scholar
- Young CL, Barker WC, Tomaselli CM, Dayhoff MO (1978) The serine proteases. In: Dayhoff MO (ed) Atlas of protein sequence and structure. NBRF, Washington, pp 73–94Google Scholar