Molecular Modelling of C3 and its Ligands

  • R. B. Sim
  • S. J. Perkins
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 153)


Progress in determining the primary structures of complement components has been very rapid during the 1980s, and, with a few minor gaps, the amino acid sequences of all of the recognised soluble components of the system have been determined from protein or DNA sequencing. The primary structures of many cell-surface components, including complement receptor types 1–4 (CR1, CR2, CR3, CR4), membrane cofactor protein (MCP) and decay-accelerating factor (DAF), all of which interact with fragments of C3, have also been derived from DNA sequences (for review see R. D. CAMPBELL et al. 1988; REID and DAY 1989; DAY 1989).


Complement Component Complement Protein Disulphide Bridge Human Complement Membrane Cofactor Protein 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. B. Sim
    • 1
  • S. J. Perkins
    • 2
  1. 1.MRC Immunochemistry Unit, Department of BiochemistryOxford UniversityOxfordUK
  2. 2.Department of Biochemistry and ChemistryRoyal Free Hospital School of Medicine, University of LondonLondonUK

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