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Participation of C3 and its Ligands in Complement Activation

  • Conference paper
Book cover The Third Component of Complement

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 153))

Abstract

The complement system comprises a group of proteins in the blood which upon activation generate fragments and protein-protein complexes expressing biological activities. The biochemistry, function, and genetics of the system have been recently reviewed (CAMPBELL et al. 1988; MÜLLER-EBERHARD 1988). Complement activation proceeds in a sequential cascase-like fashion that is similar to the activation of other humoral effector systems in the blood, such as the coagulation, the fibrinolytic, and the kinin-generating system. Complement-derived biologically active products mediate a variety of important functions including increased vascular permeability, chemotaxis of phagocytic cells, activation of inflammatory cells, opsonization of foreign particles and cells, and direct killing of foreign cells (reviewed in MÜLLEREBERHARD and MIESCHER 1985). Thus, complement plays a major role in host defense against pathogens. Accumulating evidence suggests complement activation products also function as growth and/or differentiation factors for B cells and possibly have additional effects on other cells and tissues.

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  1. Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    J. E. Volanakis

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  1. Basel Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    John D. Lambris Ph. D.

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Volanakis, J.E. (1990). Participation of C3 and its Ligands in Complement Activation. In: Lambris, J.D. (eds) The Third Component of Complement. Current Topics in Microbiology and Immunology, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74977-3_1

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  • Print ISBN: 978-3-642-74979-7

  • Online ISBN: 978-3-642-74977-3

  • eBook Packages: Springer Book Archive

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