Abstract
It is well established that lymphocytes can be reconstituted in mice with Severe Combined Immunodeficiency Disease (Bosnia et al. 1983; Dorshkind et al. 1984; Custer et al. 1985; Fulop and Phillips 1986). Engraftment of donor lymphoid precursors is facilitated by the lack of endogenous lymphocytes and the presence of a normal hemopoietic microenvironment in the mice. These and other characteristics make the Severe Combined Immunodeficient (SCID) mouse an ideal recipient in which the lymphoid differentiative potential of selected donor populations can be measured. The purpose of this chapter is to briefly review studies that have demonstrated this.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Dorshkind, K. (1989). Use of the Scid Mouse Transplantation System in Studies of Lymphocyte Differentiation. In: Bosma, M.J., Phillips, R.A., Schuler, W. (eds) The Scid Mouse. Current Topics in Microbiology and Immunology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74974-2_20
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DOI: https://doi.org/10.1007/978-3-642-74974-2_20
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