Abstract
It is believed that in scid mice the rearrangement process required for the expression of immunoglobulin (Ig) and T cell receptors (TCR) genes is defective (Bosma et al., 1983, Schuler et al., 1986). The ability to exploit this defect would provide unique opportunities to study the control of lymphocyte development by receptors encoded by rearranging gene segments.
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References
Bevan MJ (1977) In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269: 417
Bluestone J, Pardoll DM, Sharrow SO, Fowlkes BJ (1987) Characterization of murine thymocytes with CD3associated T-cell receptor structures. Nature 326: 82
Bosma GC, Custer PR, Bosma MJ (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301: 527
Crispe IN, Moore MW, Husmann LA, Smith L, Bevan MJ, Simenkavitz RP (1987) Differantiation potential of subsets of CD4–CD8- thymocytes. Nature 329: 336
Fowlkes BJ, Schwartz RH, Pardoll DM (1988) Deletion of self-reactive thymocytes occurs at a CD4+CD8+ precursor stage. Nature 334: 620
Kappler JW, Wade T, White J, Kushnir E, Blackman M, Bill J, Roehm N, Marrack PC (1987) A T cell receptor Vp segment that imparts reactivity to a class II major histocompatibility complex product. Cell 49: 263
Kisielow P, Blüthmann H, Staerz UD, Steinmetz M, von Boehmer H (1988a) Tolerance in T cell receptor transgenic mice involves deletion of nonmature CD4+8- thymocytes. Nature 333: 742
Kisielow P, Leiserson W, von Boehmer H (1984) Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2 producing cells. J.Immunol. 133: 1117
Kisielow P, Teh HS, Blüthmann H, von Boehmer H (1988b) Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335: 730
MacDonald HR, Hemgartner H, Pedrazzini T (1988) Intrathymic deletion of self-reactive cells prevented by neonatal anti CD4 antibody treatment. Nature 335: 174
Matzinger P (1981) A one receptor view of T-cell behavior. Nature 292: 497
Matzinger P, Zamoyska R, Waldmann H (1984) Self-tolerance is H-2 restricted. Nature 308: 738
Rammensee HG, Bevan MJ (1984) Evidence from in vitro studies that tolerance to self antigens is MHC-restricted. Nature 308: 741
Raulet DH, Garman RD, Saito H, Tonegawa S (1985) Developmental regulation of T-cell receptor gene expression. Nature 314: 232
Schuler W, Weiler IJ, Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ (1986) Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency (SCID). Cell 46: 963
Scott B, Blüthmann H, Teh HS, von Boehmer H (1989) The generation of mature T cells requires an interaction of the aß T cell receptor with major histocompatibility antigens. Nature in press:
Shortman K, Jackson H (1974) The differatiation of T lymphocytes I. Proliferation kinetics and interrelationships of subpopulations of mouse thymus cells. Cell.Immunol. 12: 230
Snodgrass R, Kisielow P, Kiefer H, Steinmetz M, von Boehmer H (1985) Ontogeny of the T-cell antigen receptor within the thymus. Nature 313: 592
Snodgrass RH, Dembic Z, Steinmetz M, von Boehmer H (1985) Expression of T cell antigen receptor genes during fetal development in the thymus. Nature 315: 232
Teh HS, Kishi H, Scott B, von Boehmer H (1989) Deletion of autospecific T cells in T cell receptor transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. in press:
Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Blüthmann H, von Boehmer H (1988) Thymic major histocompatibility complex antigens and the aß T cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335: 229
von Boehmer H, Haas W, Jerne NK (1978) Major histocompatibility complex linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Proc.Natl.Acad.Sci.USA 75: 2439
von Boehmer H, Teh HS, Kisielow P (1989) The thymus selects the useful, neglects the useless and destroys the harmful. Immunol.Today 10: 57
Zinkernagel RM, Callahan GN, Althage A, Cooper S, Klein PA, Klein J (1978) On the thymus in the differentiation of “H-2 self-recognition” by T cells: Evidence for dual recognition ?. J. Exp. Med. 147: 882
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© 1989 Springer-Verlag Berlin · Heidelberg
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von Boehmer, H., Blüthmann, H., Teh, H.S., Scott, B. (1989). The Utilization of the scid Mutation in the Study of T Cell Development. In: Bosma, M.J., Phillips, R.A., Schuler, W. (eds) The Scid Mouse. Current Topics in Microbiology and Immunology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74974-2_13
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DOI: https://doi.org/10.1007/978-3-642-74974-2_13
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