Abstract
The gene rearrangement mechanism in lymphocytes is a highly ordered and regulated process, containing distinct stages and tissue specificity for most of the V(D)J rearrangement events. Several lines of evidence indicate that a common “recombinase” function mediates the rearrangement process for all the immunoglobulin (Ig) and T cell receptor (TCR) gene elements. Whereas significant progress has been acheived in the molecular mapping of the organization of the Ig and TCR gene families and the structure of rearrangement products, very little progress has been made in identifying the proteins important to the recombination pathway.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Weaver, D., Hendrickson, E. (1989). The scid Mutation Disrupts Gene Rearrangement at the Rejoining of Coding Strands. In: Bosma, M.J., Phillips, R.A., Schuler, W. (eds) The Scid Mouse. Current Topics in Microbiology and Immunology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74974-2_11
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DOI: https://doi.org/10.1007/978-3-642-74974-2_11
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