Dietary Modification of the Arachidonic Acid Cascade

  • P. C. Weber
Conference paper

Abstract

Eicosanoids, the oxygenation products of arachidonic acid (AA; C20: 4n — 6) or related 20-carbon polyunsaturated fatty acids, are involved in the pathophysiology of the acute phase response and in allergic, atherothrombotic, and chronic inflammatory disorders. Interference with eicosanoid formation is characteristic of steroidal and nonsteroidal antiinflammatory agents, antiplatelet and other cardiovascular drugs, and-in conjunction with the eicosanoid receptor blockers-a target of refined pharmacological intervention strategies. A change in the arachidonic acid cascade and eicosanoid-dependent cellular functions may also be achieved by a nutritional modification of the eicosanoid precursor fatty acid pool.

Keywords

Phytoplankton Prostaglandin Triphosphate Inositol Thromboxane 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. C. Weber

There are no affiliations available

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