Dietary Modification of the Arachidonic Acid Cascade

  • P. C. Weber
Conference paper


Eicosanoids, the oxygenation products of arachidonic acid (AA; C20: 4n — 6) or related 20-carbon polyunsaturated fatty acids, are involved in the pathophysiology of the acute phase response and in allergic, atherothrombotic, and chronic inflammatory disorders. Interference with eicosanoid formation is characteristic of steroidal and nonsteroidal antiinflammatory agents, antiplatelet and other cardiovascular drugs, and-in conjunction with the eicosanoid receptor blockers-a target of refined pharmacological intervention strategies. A change in the arachidonic acid cascade and eicosanoid-dependent cellular functions may also be achieved by a nutritional modification of the eicosanoid precursor fatty acid pool.


Platelet Activate Factor Arachidonic Acid Cascade Precursor Fatty Acid Nutritional Modification Eicosanoid Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dyerberg, J, Bang, HO, Stoffersen E, Moncada S, Vane JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1:117–119CrossRefGoogle Scholar
  2. 2.
    Fischer S, Weber PC (1984) Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid. Nature 307:165–168PubMedCrossRefGoogle Scholar
  3. 3.
    Lee TH, Hoover RL, Williams JD, Sperling RI, Ravalese J, Spur BW, Robinson D, Corey EJ, Lewis RA, Austen KF (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 312:1217–1224PubMedCrossRefGoogle Scholar
  4. 4.
    v Schacky C, Weber PC (1985) Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest 76:2446–2450CrossRefGoogle Scholar
  5. 5.
    Siess W, Weber PC, Lapetina EG (1985) Different functions of phosphoinositide turnover and arachidonate metabolism for platelet activation. In: Bailey JM (ed) Prostaglandins, leukotrienes and lipoxins. Plenum, New YorkGoogle Scholar
  6. 6.
    Strasser T, Fischer S, Weber PC (1985) Leukotrine B5 is formed in human neutrophils after dietary eicosapentaenoic acid. Proc Natl Acad Sci USA 82:1540–1543PubMedCrossRefGoogle Scholar
  7. 7.
    Weber PC, Fischer S, v.Schacky C, Lorenz R, Strasser T (1986) The conversion of dietary eicosapentaenoic acid to prostanoids and leukotrienes in man. Prog Lipid Res 25:273–276PubMedCrossRefGoogle Scholar
  8. 8.
    Weber PC (1989) Epidemiologische und biochemische Studien über n-3 Fettsäuren in der Prävention der Atherosklerose. Internist (Berlin) 30:283–390Google Scholar
  9. 9.
    Leaf A, Weber PC (1988) Cardiovascular effects of n - 3 fatty acids. N Engl J Med 318:549–557PubMedCrossRefGoogle Scholar
  10. 10.
    Weber PC (1989) Clinical studies on the effects of n - 3 fatty acids on cells and eicosanoids in the cardiovascular system. J Int Med 225:61–68Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. C. Weber

There are no affiliations available

Personalised recommendations