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Pulmonary Fibrosis: Role of Inflammatory Cells in Local Injury and Fibrosis

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New Aspects on Respiratory Failure

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Abstract

Diffuse interstitial fibrosis (DIF) of the lung is characterized by the abnormal deposition of extracellular matrix (collagens, elastin, proteoglycans) with a progressive loss of functional units [1, 2]. The sequence of events leading to lung fibrosis is thought to result from a stereotyped response of the lung to an initial injury. This response involves a local inflammatory reaction (alveolitis) and the accumulation of mesenchymal cells with extracellular matrix deposition (fibrosis) [3–5].

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Authors
  1. Y. Martinet
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  2. N. Martinet
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Editor information

Editors and Affiliations

  1. Institut für Anaesthesiologie, Universität Erlangen-Nürnberg, Krankenhausstrasse 12, D-8520, Erlangen, Germany

    Erich Rügheimer

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© 1992 Springer-Verlag Berlin Heidelberg

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Martinet, Y., Martinet, N. (1992). Pulmonary Fibrosis: Role of Inflammatory Cells in Local Injury and Fibrosis. In: Rügheimer, E. (eds) New Aspects on Respiratory Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74943-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-74943-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74945-2

  • Online ISBN: 978-3-642-74943-8

  • eBook Packages: Springer Book Archive

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