Abstract
Resident macrophages are central in defending the lungs against the assaults of particles and pathogens in inspired air. The phagocytic and microbicidal potential of macrophages is one of the major reasons why the lungs remain clean and sterile. Macrophages may also prevent allergy by ingesting and catabolizing inhaled foreign proteins. Alternatively, during some lung infections they may preserve and present antigens to lymphocytes and act cooperatively with other components of the immune system to enhance the immune response. At other times lung macrophages recognize and destroy neoplastic cells, thus preventing the development of cancer. Alveolar macrophages may also ingest effete type 1 and type 2 epithelial cells, red blood cells, and perhaps even some of the “worn out” surfactant (Brain 1985).
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© 1992 Springer-Verlag Berlin Heidelberg
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Brain, J.D., Warner, A.E. (1992). The Role of Alveolar and Intravascular Macrophages in Acute Lung Injury: New Methods and New Mechanisms. In: Rügheimer, E. (eds) New Aspects on Respiratory Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74943-8_4
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DOI: https://doi.org/10.1007/978-3-642-74943-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74945-2
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