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The Pulmonary Surfactant System: Its Contribution to Lung Alveolar Stability, Alteration in Acute Respiratory Failure, and Replacement as a Therapeutical Concept

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New Aspects on Respiratory Failure

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Abstract

Sufficient amounts of biologically active pulmonary surfactant, a lipoprotein complex that lines air sacs in all mammalian lungs, are crucial for normal lung function [10]. Deficient pulmonary surfactant is the primary cause of the respiratory distress syndrome so common in premature infants [14] and alterations have also been found in adult patients with acute respiratory failure [21, 47, 48]. Therefore, replacement of deficient or inactive surfactant for the prevention and treatment of respiratory distress syndrome of various etiologies might become an important pharmacological approach. Clinical studies in new born infants have reported consistent short-term effects on lung function following tracheal instillation of both natural surfactant, derived from animal lung tissue or human amniotic fluid, and synthetic preparations [11, 25, 29]. Comparable effects have been reported for surfactant replacement in adult patients with severe respiratory failure [38].

This study was supported by Deutsche Forchungsgemeinschaft.

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Authors
  1. U. Pison
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  2. S. Hawgood
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Editors and Affiliations

  1. Institut für Anaesthesiologie, Universität Erlangen-Nürnberg, Krankenhausstrasse 12, D-8520, Erlangen, Germany

    Erich Rügheimer

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Pison, U., Hawgood, S. (1992). The Pulmonary Surfactant System: Its Contribution to Lung Alveolar Stability, Alteration in Acute Respiratory Failure, and Replacement as a Therapeutical Concept. In: Rügheimer, E. (eds) New Aspects on Respiratory Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74943-8_19

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  • DOI: https://doi.org/10.1007/978-3-642-74943-8_19

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