Residues of Carbadox Metabolites in Edible Pork Products
Carbadox (methyl-3-[2-quinoxalinylmethylene]carbazate-N1, N4-dioxide; CBX) is a widely used feed additive for young pigs (Trasher et al 1969), but because of its adrenal toxicity there is some risk in using it (Van der Molen et al 1985, 1986). CBX is rapidly metabolized; known biotransformation products involve the three N-O-reduced compounds (N1-, N4-, and N1,N4-desoxycarbadox; DCBX), and quinoxaline-2-carboxylic acid (QCA). QCA has been identified as the major residual metabolite in pigs (Federal Register 1972; Ferrando et al 1975). Since CBX and DCBX are suspected carcinogens, CBX may only be administered to swine under the age of 4 months, and a withdrawal period of 4 weeks has been imposed.
KeywordsToxicity HPLC Aldosterone Tral Biotransformation
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