Abstract
Carbon monoxide as a poison is responsible for a large number of deaths and a great amount of morbidity. Hyperglycemia is reported to modify the outcome in global cerebral and spinal cord ischemia (LeMay et al 1987; Siemkowicz and Hansen 1978), cardiac arrest (Lundy et al 1987), and stroke (Pulsinelli et al 1983). This is of particular relevance to acute carboxyhemoglobinemia because hyperglycemia usually accompanies CO poisoning. The aim of this study was to evaluate the role of plasma glucose concentration in the outcome from acute severe CO poisoning in an animal model.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Laas R, Igloffstein J, Meyerhoff S (1983) Cerebral infarction due to carotid occlusion and carbon monoxide exposure. I. Pathophysiological and neuropathological investigations. J Neurol Neurosurg Psychiatr 46:756–767
LeMay DR, Neal S, Neal S, Zelenock GB, D’Alecy LG (1987) Paraplegia in the rat induced by aortic cross-clamping: Model characterization and glucose exacerbation of neurologic deficit. Vascular Surg 6:383–390
Lundy EF, Dykstra J, Luyckx B, Zelenock GB, D’Alecy LG (1985) Reduction of neurologic deficit by 1,3-butanediol induced ketosis in Levine rats. Stroke 16:855–860
Lundy EF, Kuhn JE, Kwon JW, Zelenock GB, D’Alecy LG (1987) Infusion of five percent dextrose increases mortality and morbidity following six minutes of cardiac arrest in resuscitated dogs. J Crit Care 2:4–14
MacMillan V (1975) Regional cerebral blood flow of the rat in acute carbon monoxide intoxication. Can J Physiol Pharmacol 53:644–650
Nordstrom CH, Rehnchrona S, Siesjo BK (1976) Restitution of cerebral energy state after complete and incomplete ischemia of 30 min duration. Acta Physiol Scand 97:270–272
Penney DG (1988) Hyperglycemia exacerbates brain damage in acute severe carbon monoxide poisoning. Med Hypotheses 27:241–244
Penney DG, Verma K, Hull JA (1989) Cardiovascular, metabolic and neurologic effects of acute carbon monoxide poisoning in the rat. Toxicol Letts 45:207–213
Pulsinelli WA, Levy DE, Sigsbee B, Scherer P, Plum F (1983) Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus. Am J Med 74:540–544
Rehncrona S, Rosen I, Siesjo BK (1980) Excessive cellular acidosis: An important mechanism of neuronal damage in the brain. Acta Physiol Scand 110:435–437
Siemkowicz E, Hansen AJ (1978) Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats. Acta Neurol Scand 58: 1–8
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Penney, D.G. (1991). Modifying Role of Plasma Glucose in Acute Carbon Monoxide Poisoning. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_50
Download citation
DOI: https://doi.org/10.1007/978-3-642-74936-0_50
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51422-0
Online ISBN: 978-3-642-74936-0
eBook Packages: Springer Book Archive